Hideaki TAGAMI

	Hideaki TAGAMI Associate Professor, Doctor of Science
	E-mail: dan TEL: +81-52-872-5818 FAX: +81-52-872-5818 Research Course: Biological Science
	URL　http://www.nsc.nagoya-cu.ac.jp/~dan/
Specialties	Molecular Biology, Chromatin Regulation
Keywords	Histone complex, Chromatin regulation
Current Research	The research of this group focuses on chromatin regulation using a strategy of protein complex analysis. We address the molecular mechanisms through functional analyses of the interaction partners of histones in yeast. The major projects are following: (1) Molecular mechanisms of chromatin assembly We are studying the histone deposition machineries to understand the molecular events leading to chromatin assembly. (2) Chromatin regulation on gene expression We are interested in the connections between the histone dynamics and transcription. (3) Histone metabolism and cell cycle We investigate the regulations of histone’s life: from the synthesis to degradation, and the molecular link between the regulation and cell cycle progression.
Selected Papers	HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres., Cell, 137, 487-497 (2009). From the view of histone complexes: A sketch of molecular players on the chromatin assembly events. In "DNA Structure, Chromatin and Gene Expression" Transworld Research Network, 57, 145-158 (2006). Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis, Cell, 116, 51-61 (2004).