Publications

new 36) Yamada M, Okutsu M. Interleukin-1β triggers muscle-derived extracellular superoxide dismutase expression and protects muscles from doxorubicin-induced atrophy. J Physiol. Accepted.

new 35) Yamada M, Warabi E, Oishi H, Lira VA, Okutsu M. Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia. FASEB J. 37(9):e23156, 2023.

34) Okutsu M, Yamada M, Tokizawa K, Marui S, Suzuki K, Lira VA, Nagashima K. Regular exercise stimulates endothelium autophagy via IL-1 signaling in ApoE deficient mice. FASEB J. 35(7):e21698, 2021.

33) Onoki T, Izumi Y, Takahashi M, Murakami S, Matsumaru D, Ohta N, Wati SM, Hatanaka N, Katsuoka F, Okutsu M Yabe Y, Hagiwara Y, Kanzaki M, Bamba T, Itoi E, Motohashi H. Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice. Redox Biol. 43:101966, 2021.

32) Yamada M, Hokazono C, Tokizawa K, Marui S, Iwata M, Lira VA, Suzuki K, Miura S, Nagashima K, Okutsu M. Muscle-derived SDF-1α/CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis. Am J Physiol Regul Integr Comp Physiol. 317(6):R770-779, 2019.

31) Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M. p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J. 33(7):8022-8032, 2019.

30) Yamada M, Hokazono C, Okutsu M Maternal exercise training attenuates endotoxin-induced sepsis in mice offspring. Biochem Biophys Rep. 15:19-24, 2018.

29) Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M Du Z, Lira VA, Zhang M, Mehrad B, Annex BH, Klibanov AL, Bowler RP, Laubach VE, Peirce SM, Yan Z. Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free Radic Biol Med. 113:212-223, 2017.

28) Dokun AO, Chen L, Okutsu M Farber CR, Hazarika S, Jones WS, Craig D, Marchuk DA, Lye RJ, Shah SH, Annex BH. ADAM12: A Genetic Modifier of Pre-clinical Peripheral Arterial Disease. Am J Physiol Heart Circ Physiol. 309(5):H790-803, 2015.

27) Call JA, Kristopher C, Martin K, Lira VA, Okutsu M, Zhang M, Yan Z.
Enhanced skeletal muscle expression of EcSOD mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling. Circulation Heart Fail. 8(1):188-97, 2015.

26) Okutsu M, Ishii K, Niu K, Nagatomi R. Cortisol is not the primary mediator for augmented CXCR4 expression on natural killer cells after acute exercise. J Appl Physiol. 117(3):199-204, 2014.

25) Okutsu M, Lira VA, Zhang M, Call JA, Donet JA, French BA, Martin K, Sanders JA, Peirce-Cottler SM, Rembold CM, Annex BH Yan Z. Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia and exercise intolerance in mice with congestive heart failure. Circulation Heart Fail. 7(3):519-30, 2014.（Editor's Picksに選出）

24) Laker RC, Lillard TS, Okutsu M, Zhang M, Hoehn KL, Connelly JJ, Yan Z. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes. 63(5):1605-11, 2014.

23) Okutsu M, Lira VA, Higashida K, Peake J, Higuchi M, Suzuki K. Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse. Atherosclerosis. 232(2):414-9, 2014.

22) Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, Hoehn KL, Yan Z. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J. 27(10):4184-93, 2013.

21) Zhang C, He Y, Okutsu M, Ong LC, Jin Y, Zheng L, Chow P, Yu S, Zhang M, Yan Z. Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation. Am J Physiol Endocrinol Metab. 305(4):E530-9, 2013.

20) Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Jung DY, Okutsu M, Yan Z, Kim JK, Lin JD. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Med. 19(5):640-5, 2013.

19) Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Rep. 3(5):1449-56, 2013.

18) Ruas JL, White JP, Rao1 RR, Brannan KT, Harrison BC, Greene NP, Kleiner S, Wu J, Estall JL, Irving VB, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. A novel PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 151(6):1319-31, 2012.

17) Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 109(17):6739-44, 2012.

16) Wada S, Kato Y, Okutsu M, Miyaki S, Suzuki K, Yan Z, Schiaffino S, Asahara H, Ushida T, Akimoto T. Translational suppression of atrophic regulators by miR-23a integrates resistance to skeletal muscle atrophy. J Biol Chem. 286(44):38456-65, 2011.

15) Yan Z, Okutsu M, Lira VA, Akhtar YN. Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol. 110(1):264-74, 2011.

14) Ogawa K, Sanada K, Machida S, Okutsu M, Suzuki K. Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women. Mediators of Inflammation. 2010:171023, 2010.

13) Geng T, Li P, Okutsu M, Yin X, Kwek J, Zhang M, Yan Z. PGC-1 alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. Am J Physiol Cell Physiol. 298(3):C572-9, 2010.

12) Ogawa K, Suzuki K, Okutsu M, Yamazaki K, Shinkai S. The association of elevated reactive oxygen species level from neutrophils with low-grade Inflammation in the elderly. Immune Aging 5:13, 2008.

11) Okutsu M, Yoshida Y, Zhang X, Tamagawa A, Ohkubo T, Tsuji I, Nagatomi R. Exercise training enhances in vivo tuberculosis purified protein derivative response in the elderly. J Appl Physiol. 104(6):1690-6, 2008.

10) Okutsu M, Suzuki K, Ishijima T, Peake J, Higuchi M. The effects of acute exercise-induced cortisol on CCR2 expression on human monocytes. Brain Behav Immunity. 22(7):1066-71, 2008.

9) Peake J, Abbiss C, Peiffer J, Nosaka K, Okutsu M, Laursen PB, Suzuki K. Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise. Eur J Appl Physiol. 102(4):391-401, 2008.

8) Shing CM, Peake J, Suzuki K, Okutsu M, Pereira R, Stevenson L, Jenkins DG, Coombes JS. Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. J Appl Physiol. 102(3):1113-22, 2007.

7) Suzuki K, Peake J, Nosaka K, Okutsu M, Abbiss CR, Surriano R, Bishop D, Quod MJ, Lee H, Martin DT, Laursen PB. Changes in markers of muscle damage, inflammation and HSP70 after an Ironman Triathlon race. Eur J Appl Physiol. 98(6):525-34. 2006.

6) Niu K, Hozawa A, Fujita K, Ohmori K, Okutsu M, Kuriyama S, Tsuji I, Nagatomi R. Influence of leisure-time physical activity on the relationship between c-reactive protein and hypertension in a community-based elderly population of Japan: the Tsurugaya project. Hypertens Res. 28(9):747-54, 2005.

5) Zhang X, Okutsu M, Kanemi O, Nagatomi R. Effect of foot shock stress on the interferon-gamma production of murine intestinal intraepithelial lymphocytes. Immunol Lett. 100(2):170-6, 2005.

4) Zhang X, Okutsu M, Kanemi O, Gametchu B, Nagatomi R. Repeated stress suppresses interferon-gamma production by murine intestinal intraepithelial lymphocytes. Tohoku J Exp Med. 206(3):203-12, 2005.

3) Okutsu M, Ishii K, Niu KJ, Nagatomi R. Cortisol-induced CXCR4 augmentation mobilizes T lymphocytes after acute physical stress. Am J Physiol Regul Integr Comp Physiol. 288(3):R591-9, 2005.

2) Nagatomi R, Kaifu T, Okutsu M, Zhang X, Kanemi O, Ohmori H. Modulation of the immune system by the autonomic nervous system and its implication in immunological changes after training. Exerc Immunol Rev. 6:54-74, 2000.

1) Miyachi M, Iemitsu M, Okutsu M, Onodera S. Effects of endurance training on the size and blood flow of the arterial conductance vessels in humans. Acta Physiol Scand. 163(1):13-6, 1998.