学術論文
欧文誌
new 36) Yamada M, Okutsu M. Interleukin-1β triggers muscle-derived extracellular superoxide dismutase expression and protects muscles from doxorubicin-induced atrophy. J Physiol. 601(21):4699-4721, 2023.

new 35) Yamada M, Warabi E, Oishi H, Lira VA, Okutsu M. Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia. FASEB J. 37(9):e23156, 2023.

34) Okutsu M, Yamada M, Tokizawa K, Marui S, Suzuki K, Lira VA, Nagashima K. Regular exercise stimulates endothelium autophagy via IL-1 signaling in ApoE deficient mice. FASEB J. 35(7):e21698, 2021.

33) Onoki T, Izumi Y, Takahashi M, Murakami S, Matsumaru D, Ohta N, Wati SM, Hatanaka N, Katsuoka F, Okutsu M, Yabe Y, Hagiwara Y, Kanzaki M, Bamba T, Itoi E, Motohashi H. Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice. Redox Biol. 43:101966, 2021.

32) Yamada M, Hokazono C, Tokizawa K, Marui S, Iwata M, Lira VA, Suzuki K, Miura S, Nagashima K, Okutsu M. Muscle-derived SDF-1α/CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis. Am J Physiol Regul Integr Comp Physiol. 317(6):R770-779, 2019.

31) Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M. p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J. 33(7):8022-8032, 2019.

30) Yamada M, Hokazono C, Okutsu M Maternal exercise training attenuates endotoxin-induced sepsis in mice offspring. Biochem Biophys Rep. 15:19-24, 2018.

29) Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M Du Z, Lira VA, Zhang M, Mehrad B, Annex BH, Klibanov AL, Bowler RP, Laubach VE, Peirce SM, Yan Z. Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free Radic Biol Med. 113:212-223, 2017.

28) Dokun AO, Chen L, Okutsu M Farber CR, Hazarika S, Jones WS, Craig D, Marchuk DA, Lye RJ, Shah SH, Annex BH. ADAM12: A Genetic Modifier of Pre-clinical Peripheral Arterial Disease. Am J Physiol Heart Circ Physiol. 309(5):H790-803, 2015.

27) Call JA, Kristopher C, Martin K, Lira VA, Okutsu M, Zhang M, Yan Z.
Enhanced skeletal muscle expression of EcSOD mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling. Circulation Heart Fail. 8(1):188-97, 2015.

26) Okutsu M, Ishii K, Niu K, Nagatomi R. Cortisol is not the primary mediator for augmented CXCR4 expression on natural killer cells after acute exercise. J Appl Physiol. 117(3):199-204, 2014.

25) Okutsu M, Lira VA, Zhang M, Call JA, Donet JA, French BA, Martin K, Sanders JA, Peirce-Cottler SM, Rembold CM, Annex BH Yan Z. Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia and exercise intolerance in mice with congestive heart failure. Circulation Heart Fail. 7(3):519-30, 2014.(Editor's Picksに選出)

24) Laker RC, Lillard TS, Okutsu M, Zhang M, Hoehn KL, Connelly JJ, Yan Z. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes. 63(5):1605-11, 2014.

23) Okutsu M, Lira VA, Higashida K, Peake J, Higuchi M, Suzuki K. Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse. Atherosclerosis. 232(2):414-9, 2014.

22) Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, Hoehn KL, Yan Z. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J. 27(10):4184-93, 2013.

21) Zhang C, He Y, Okutsu M, Ong LC, Jin Y, Zheng L, Chow P, Yu S, Zhang M, Yan Z. Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation. Am J Physiol Endocrinol Metab. 305(4):E530-9, 2013.

20) Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Jung DY, Okutsu M, Yan Z, Kim JK, Lin JD. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Med. 19(5):640-5, 2013.

19) Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Rep. 3(5):1449-56, 2013.

18) Ruas JL, White JP, Rao1 RR, Brannan KT, Harrison BC, Greene NP, Kleiner S, Wu J, Estall JL, Irving VB, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. A novel PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 151(6):1319-31, 2012.

17) Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 109(17):6739-44, 2012.

16) Wada S, Kato Y, Okutsu M, Miyaki S, Suzuki K, Yan Z, Schiaffino S, Asahara H, Ushida T, Akimoto T. Translational suppression of atrophic regulators by miR-23a integrates resistance to skeletal muscle atrophy. J Biol Chem. 286(44):38456-65, 2011.

15) Yan Z, Okutsu M, Lira VA, Akhtar YN. Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol. 110(1):264-74, 2011.

14) Ogawa K, Sanada K, Machida S, Okutsu M, Suzuki K. Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women. Mediators of Inflammation. 2010:171023, 2010.

13) Geng T, Li P, Okutsu M, Yin X, Kwek J, Zhang M, Yan Z. PGC-1 alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. Am J Physiol Cell Physiol. 298(3):C572-9, 2010.

12) Ogawa K, Suzuki K, Okutsu M, Yamazaki K, Shinkai S. The association of elevated reactive oxygen species level from neutrophils with low-grade Inflammation in the elderly. Immune Aging. 5:13, 2008.

11) Okutsu M, Yoshida Y, Zhang X, Tamagawa A, Ohkubo T, Tsuji I, Nagatomi R. Exercise training enhances in vivo tuberculosis purified protein derivative response in the elderly. J Appl Physiol. 104(6):1690-6, 2008.

10) Okutsu M, Suzuki K, Ishijima T, Peake J, Higuchi M. The effects of acute exercise-induced cortisol on CCR2 expression on human monocytes. Brain Behav Immunity. 22(7):1066-71, 2008.

9) Peake J, Abbiss C, Peiffer J, Nosaka K, Okutsu M, Laursen PB, Suzuki K. Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise. Eur J Appl Physiol. 102(4):391-401, 2008.

8) Shing CM, Peake J, Suzuki K, Okutsu M, Pereira R, Stevenson L, Jenkins DG, Coombes JS. Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. J Appl Physiol. 102(3):1113-22, 2007.

7) Suzuki K, Peake J, Nosaka K, Okutsu M, Abbiss CR, Surriano R, Bishop D, Quod MJ, Lee H, Martin DT, Laursen PB. Changes in markers of muscle damage, inflammation and HSP70 after an Ironman Triathlon race. Eur J Appl Physiol. 98(6):525-34. 2006.

6) Niu K, Hozawa A, Fujita K, Ohmori K, Okutsu M, Kuriyama S, Tsuji I, Nagatomi R. Influence of leisure-time physical activity on the relationship between c-reactive protein and hypertension in a community-based elderly population of Japan: the Tsurugaya project. Hypertens Res. 28(9):747-54, 2005.

5) Zhang X, Okutsu M, Kanemi O, Nagatomi R. Effect of foot shock stress on the interferon-gamma production of murine intestinal intraepithelial lymphocytes. Immunol Lett. 100(2):170-6, 2005.

4) Zhang X, Okutsu M, Kanemi O, Gametchu B, Nagatomi R. Repeated stress suppresses interferon-gamma production by murine intestinal intraepithelial lymphocytes. Tohoku J Exp Med. 206(3):203-12, 2005.

3) Okutsu M, Ishii K, Niu KJ, Nagatomi R. Cortisol-induced CXCR4 augmentation mobilizes T lymphocytes after acute physical stress. Am J Physiol Regul Integr Comp Physiol. 288(3):R591-9, 2005.

2) Nagatomi R, Kaifu T, Okutsu M, Zhang X, Kanemi O, Ohmori H. Modulation of the immune system by the autonomic nervous system and its implication in immunological changes after training. Exerc Immunol Rev. 6:54-74, 2000.

1) Miyachi M, Iemitsu M, Okutsu M, Onodera S. Effects of endurance training on the size and blood flow of the arterial conductance vessels in humans. Acta Physiol Scand. 163(1):13-6, 1998.

和文誌(報告書を含む)
new 10) 山田麻未奥津光晴.運動によるマイトファジーの活性化に対するp62の役割. デサントスポーツ科学 43:71-79, 2022.

9) 奥津光晴,山田麻未.運動による骨格筋の毛細血管密度の制御に対するマイオカインの役割.デサントスポーツ科学 41:192-198,2020.

8) 奥津光晴,山田麻未.骨格筋の恒常性維持に関する最新知見. 体力科学 67(3):245-249, 2018.

7) 奥津光晴,山田麻未.一酸化窒素による骨格筋萎縮の抑制と分子メカニズムの解明.医科学応用究財団論文集 34:272-275, 2017.

6) 奥津光晴.運動による脂肪組織の恒常性維持に対するオートファジーの役割.デサントスポーツ科学 37:161-170,2016.

5) 奥津光晴.定期的運動による動脈硬化症予防の新規分子メカニズムの解明.健康科学研究助成成果報告書 30:81-86, 2015.

4) 近藤隆正,小川貴志子,寺田修,金奇人,奥津光晴,鈴木克彦.寒冷環境が運動負荷によるサイトカイン応答に及ぼす影響.日本補完代替医療学会誌 6(2):89-95, 2009.

3) 山谷金光,鈴木克彦,野坂和則,小川貴志子,奥津光晴,Daniel Galvão,Jonathan Peake,Robert Newton.男性ホルモン除去療法(ADT)中の前立腺癌患者に対するレジスタンストレーニングの効果.日本補完代替医療学会誌 5(1): 57-63, 2008.

2) 山内武巳,北村勝朗,高戸仁郎,安田俊広,奥津光晴.スノーボードロングターンカービングの筋電図による動作分析.東北体育学研究23:31−37, 2005.

1) 宮地元彦,奥津光晴,中原英博,斉藤剛.8週間の持久的トレーニングが人の下大静脈横断面積に及ぼす影響.体力科学 48:91-98, 1999.

著書
12) 奥津光晴運動と運動器健康づくりの新・運動生理学(上田伸男, 矢野博已編集), アイ・ケイ コーポレーション. 2021.

11) 奥津光晴,山田麻未.筋肉の基本構造と恒常性. 筋肉研究最前線(森谷敏夫編集), NTS. 2019.

10) 奥津光晴. 運動によるオートファジーの調節と動脈硬化症予防. 体育の科学, 杏林書院. 66巻1月号. 30-35, 2016.

9) 奥津光晴. スポーツと酸化ストレス. 「新•スポーツ生理学」(村岡功編著), 市村出版. 187-196, 2015.

8) 奥津光晴. 運動と免疫(リンパ球). 「ニュー運動生理学II」(宮村実晴編集), 真興出版. 375-383, 2015.

7) 奥津光晴, 秋本崇之. 運動がPGC-1αを介してもたらすヘルス・ベネフィットの分子メカニズムを探る. 臨床スポーツ医学, 文光堂. 30巻10月号. 977-981, 2013.

6) 奥津光晴. カヘキシーによる筋萎縮. 体育の科学, 杏林書院. 60巻12月号. 841-844, 2010.

5) 奥津光晴. 運動と免疫. 「運動生理学のニューエビデンス」(宮村実晴編集), 真興出版. 452-457, 2010.

4) 奥津光晴. かぜをひきやすい、だるい、疲労感.「免疫病気予防百科」(渡邉昌、和田攻総監修), 日本医療企画. 184-185, 2007.

3) 奥津光晴. 食物依存性運動誘発アナフィラキシー.「免疫病気予防百科」(渡邉昌、和田攻総監修), 日本医療企画. 176-177, 2007.

2) 永富良一,奥津光晴. 細菌やウィルス感染に対する免疫力の指標としてどのようなものがあるか?日本医事新報. 4134:143-144, 2003.

1) 永富良一,奥津光晴. 免疫系とトレーニング. 「トレーニング生理学」(芳賀脩光,大野秀樹編), 杏林書院. 297-307, 2003.

その他
3) 奥津光晴.筋肉痛が起きるメカニズム.日本経済新聞.2020年12月12日

2) 奥津光晴.骨格筋の恒常性を調節する因子の探索と応用.科学新聞.2017年3月17日

1) 奥津光晴.運動分子生物学.中部経済新聞「研究現場発」.2015年4月14日