研究成果 of 非コードDNA

Kobayashi T.
Genome Instability of Repetitive Sequence: Lesson from the Ribosomal RNA Gene Repeat.
“DNA Replication, Recombination, and Repair” Hanaoka, F and Sugasawa K. ed. Part IV, Chapter 10; 235-247. (2016)

Saka K, Takahashi A, Sasaki M, Kobayashi T.
More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance.
Nucleic Acids Res. 44(9):4211-21. (2016)

Akamatsu Y, Kobayashi T.
The Human PolI Transcription Terminator Complex Acts as a Replication Fork Barrier that Coordinates the Progress of Replication with rRNA Transcription Activity.
Mol Cell Biol. 35(10):1871-81. (2015)

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Mitsumori R, Ohashi T, Kugou K, Ichino A, Taniguchi K, Ohta K, Uchida H, Oki M.
Analysis of novel Sir3 binding regions in Saccharomyces cerevisiae.
J Biochem. 160(1): 11-7 (2016)

Takemata N, Oda A, Yamada T, Galipon J, Miyoshi T, Suzuki Y, Sugano S, Hoffman CS, Hirota K, Ohta K.
Local potentiation of stress-responsive genes by upstream noncoding transcription.
Nucleic Acids Res. in press (2016)

Tashiro S, Handa T, Matsuda A, Ban T, Takigawa T, Miyasato K, Ishii K, Kugou K, Ohta K, Hiraoka Y, Masukata H, Kanoh J.
Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.
Nat Commun. 7:10393. (2016)

Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P, Inoue A, Nabetani T, Murayama A, Ohta K, Ito Y, Aoki J, Hirabayashi Y, Kamiguchi H.
NEURONAL DEVELOPMENT. Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord.
Science. 349(6251):974-7. (2015)

Oda A, Takemata N, Hirata Y, Miyoshi T, Suzuki Y, Sugano S, Ohta K.
Dynamic transition of transcription and chromatin landscape during fission yeast adaptation to glucose starvation.
Genes Cells. 20(5):392-407 (2015)

Ozawa T, Ohta K, Shimada M, Okada K, Okada Y.
Environmental Factors Affecting Pupation Decision in the Horned Flour Beetle Gnatocerus cornutus.
Zoolog Sci. 32(2):183-7. (2015)

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Nishi E, Masuda K, Arakawa M, Kawame H, Kosho T, Kitahara M, Kubota N, Hidaka E, Katoh Y, Shirahige K, Izumi K.
Exome sequencing-based identification of mutations in non-syndromic genes among individuals with apparently syndromic features.
Am J Med Genet A. (2016) in press

Izumi K, Brett M, Nishi E, Drunat S, Tan ES, Fujiki K, Lebon S, Cham B, Masuda K, Arakawa M, Jacquinet A, Yamazumi Y, Chen ST, Verloes A, Okada Y, Katou Y, Nakamura T, Akiyama T, Gressens P, Foo R, Passemard S, Tan EC, El Ghouzzi V, Shirahige K.
ARCN1 Mutations Cause a Recognizable Craniofacial Syndrome Due to COPI-Mediated Transport Defects.
Am J Hum Genet. 99(2):451-9. (2016)

Koya J, Kataoka K, Sato T, Bando M, Kato Y, Tsuruta-Kishino T, Kobayashi H, Narukawa K, Miyoshi H, Shirahige K, Kurokawa M.
DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation.
Nat Commun. 7:10924. (2016)

Minamino M, Ishibashi M, Nakato R, Akiyama K, Tanaka H, Kato Y, Negishi L, Hirota T, Sutani T, Bando M, Shirahige K.
Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.
Curr Biol. 25(13):1694-706. (2015)

Masuda K, Akiyama K, Arakawa M, Nishi E, Kitazawa N, Higuchi T, Katou Y, Shirahige K, Izumi K.
Exome Sequencing Identification of EP300 Mutation in a Proband with Coloboma and Imperforate Anus: Possible Expansion of the Phenotypic Spectrum of Rubinstein-Taybi Syndrome.
Mol Syndromol. 6(2):99-103. (2015)

Kubota T, Katou Y, Nakato R, Shirahige K, Donaldson AD.
Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation.
Cell Rep. 12(5):774-87. (2015)

Kurimoto K, Yabuta Y, Hayashi K, Ohta H, Kiyonari H, Mitani T, Moritoki Y, Kohri K, Kimura H, Yamamoto T, Katou Y, Shirahige K, Saitou M.
Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells.
Cell Stem Cell. 16(5):517-32. (2015)

Izumi K, Nakato R, Zhang Z, Edmondson AC, Noon S, Dulik MC, Rajagopalan R, Venditti CP, Gripp K, Samanich J, Zackai EH, Deardorff MA, Clark D, Allen JL, Dorsett D, Misulovin Z, Komata M, Bando M, Kaur M, Katou Y, Shirahige K, Krantz ID.
Germline gain-of-function mutations in AFF4 cause a developmental syndrome functionally linking the super elongation complex and cohesin.
Nat Genet. 47(4):338-44. (2015)

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Fawcett JA, Innan H.
High similarity between distantly related species of a plant SINE family is consistent with a scenario of vertical transmission without horizontal transfers.
Mol Biol Evol. (2016) in press

Fawcett JA, Innan H.
Spreading good news.
Elife. 4. doi: 10.7554/eLife.07108 (2015)

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Kamata K, Shinmyozu K, Nakayama J, Hatashita M, Uchida H, Oki M.
Four domains of Ada1 form a heterochromatin boundary through different mechanisms.
Genes Cells (2016) in press

Mitsumori R, Shinmyozu K, Nakayama JI, Uchida H, Oki M.
Gic1 is a novel heterochromatin boundary protein in vivo.
Genes Genet Syst. (2016) in press

Shimojo H, Kawaguchi A, Oda T, Hashiguchi N, Omori S, Moritsugu K, Kidera A, Hiragami-Hamada K, Nakayama J, Sato M, Nishimura Y.
Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail.
Sci Rep. 6:22527 (2016)

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Wakamori M, Fujii Y, Suka N, Shirouzu M, Sakamoto K, Umehara T, Yokoyama S.
Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation.
Sci Rep. 5:17204 (2015)

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Irie M, Koga A, Kaneko-Ishino T, Ishino F.
An LTR Retrotransposon-Derived Gene Displays Lineage-Specific Structural and Putative Species-Specific Functional Variations in Eutherians.
Front Chem. (2016) in press

Kugou K, Hirai H, Masumoto H, Koga A
Formation of functional CENP-B boxes at diverse locations in repeat units of centromeric DNA in New World monkeys
Sci Rep. 6:27833. (2016)

Suntronpong A, Kugou K, Masumoto H, Srikulnath K, Ohshima K, Hirai H, Koga A.
CENP-B box, a nucleotide motif involved in centromere formation, occurs in a New World monkey.
Biol Lett. 12(3): pii:20150817 (2016)

Sujiwattanarat P, Thapana W, Srikulnath K, Hirai Y, Hirai H, Koga A.
Higher-order repeat structure in alpha satellite DNA occurs in New World monkeys and is not confined to hominoids.
Sci Rep. 5:10315 (2015)

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Yamaguchi K, Kajikawa M, Okada N.
LINE retrotransposition and host DNA repair machinery.
Mob Genet Elements. 5(6):92-97. (2015)

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Keyamura K, Arai K, Hishida T.
Srs2 and Mus81-Mms4 prevent accumulation of toxic inter-homolog recombination intermediates.
PLoS Genet. (2016) in press

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Ohzeki J, Shono N, Otake K, Martins NM, Kugou K, Kimura H, Nagase T, Larionov V, Earnshaw WC, Masumoto H.
KAT7/HBO1/MYST2 regulates CENP-A chromatin assembly by antagonizing Suv39h1-mediated centromere inactivation.
Dev Cell 37(5):413-27. (2016)

Kugou K, Hirai H, Masumoto H, Koga A
Formation of functional CENP-B boxes at diverse locations in repeat units of centromeric DNA in New World monkeys
Sci Rep. 6:27833. (2016)

Suntronpong A, Kugou K, Masumoto H, Srikulnath K, Ohshima K, Hirai H, Koga A.
CENP-B box, a nucleotide motif involved in centromere formation, occurs in a New World monkey.
Biol Lett. 12(3): pii:20150817 (2016)

Kim JH, Lee HS, Lee NC, Goncharov NV, Kumeiko V, Masumoto H, Earnshaw WC, Kouprina N, Larionov V.
Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells.
Oncotarget. 7(12): 14841-56 (2016)

Martins NM, Bergmann JH, Shono N, Kimura H, Larionov V, Masumoto H, Earnshaw WC.
Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3.
Mol Biol Cell 27(1): 177-96 (2016)

Shono N, Ohzeki J, Otake K, Martins NM, Nagase T, Kimura H, Larionov V, Earnshaw WC, Masumoto H.
CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
J Cell Sci. 128(24): 4572-87 (2015)

Fujita R, Otake K, Arimura Y, Horikoshi N, Miya Y, Shiga T, Osakabe A, Tachiwana H, Ohzeki J, Larionov V, Masumoto H, Kurumizaka H.
Stable complex formation of CENP-B with the CENP-A nucleosome.
Nucleic Acids Res. 43(10):4909-22. (2015)

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Tashiro S, Handa T, Matsuda A, Ban T, Takigawa T, Miyasato K, Ishii K, Kugou K, Ohta K, Hiraoka Y, Masukata H, Kanoh J.
Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.
Nat Commun. 7:10393. (2016)

Deng W, Wu J, Wang F, Kanoh J, Dehe PM, Inoue H, Chen J, Lei M.
Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2.
Cell Res. 25(7):881-4. (2015)

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Katsuki Y, Takata M.
Defects in HR repair behind the human diseases: FA and HBOC.
Endocr Relat Cancer. (2016) in press

Osawa M, Ohashi K, Kubo T, Ichikawa E, Takata S, Takigawa N, Takata M, Tanimoto M, Kiura K.
Effect of vandetanib on lung tumorigenesis in transgenic mice carrying an activating Egfr gene mutation.
Acta Med Okayama. 70(4):243-53. (2016)

Ohashi K, Hotta K, Hirata T, Aoe K, Kozuki T, Ninomiya K, Kayatani H, Yanai H, Toyooka S, Hinotsu S, Takata M, Kiura K.
Trastuzumab Emtansine in HER2+ recurrent metastatic non-small-cell lung cancer: study protocol.
Clin Lung Cancer. (2016) in press

Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J.
Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.
Oncotarget. (2016) in press

Yabe M, Yabe H, Morimoto T, Fukumura A, Ohtsubo K, Koike T, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Hira A, Takata M.
The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype.
Br J Haematol. (2016) in press

Takata K, Tomida J, Reh S, Swanhart LM, Takata M, Hukriede NA, Wood RD.
Conserved Overlapping Gene Arrangement, Restricted Expression, and Biochemical Activities of DNA Polymerase ν (POLN).
J Biol Chem. 290(40):24278-93. (2015)

Hira A, Yoshida K, Sato K, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Shimamoto A, Tahara H, Ito E, Kojima S, Kurumizaka H, Ogawa S, Takata M, Yabe H, Yabe M.
Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.
Am J Hum Genet. 96(6):1001-7. (2015)

Takahashi D, Sato K, Hirayama E, Takata M, Kurumizaka H.
Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA.
J Biochem. 58(3):263-70.

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Tanaka K, Hirota T.
Chromosomal instability: A common feature and a therapeutic target of cancer.
Biochim Biophys Acta. 1866(1):64-75. (2016)

Takahashi M, Tanaka K, Wakai T, Hirota T.
Phosphoproteomic analysis of human mitotic chromosomes identified a chromokinesin KIF4A.
Biomed Res. 37(2):161-5. (2016)

Hasanpourghadi M, Karthikeyan C, Pandurangan AK, Looi CY, Trivedi P, Kobayashi K, Tanaka K, Wong WF, Mustafa MR.
Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.
J Exp Clin Cancer Res. 35:58. (2016)

Isidor B, Küry S, Rosenfeld JA, Besnard T, Schmitt S, Joss S, Davies SJ, Lebel RR, Henderson A, Schaaf CP, Streff HE, Yang Y, Jain V, Chida N, Latypova X, Le Caignec C, Cogné B, Mercier S, Vincent M, Colin E, Bonneau D, Denommé AS, Parent P, Gilbert-Dussardier B, Odent S, Toutain A, Piton A, Dina C, Donnart A, Lindenbaum P, Charpentier E, Redon R, Iemura K, Ikeda M, Tanaka K, Bézieau S.
De novo truncating mutations in the kinetochore-microtubules attachment gene CHAMP1 cause syndromic intellectual disability.
Hum Mutat. 37(4):354-8. (2016)

Amin MA, Kobayashi K, Tanaka K.
CLIP-170 tethers kinetochores to microtubule plus ends against poleward force by dynein for stable kinetochore-microtubule attachment.
FEBS Lett. 589(19 Pt B):2739-46. (2015)

Ohira M, Iwasaki Y, Tanaka C, Kuroki M, Matsuo N, Kitamura T, Yukuhiro M, Morimoto H, Pang N, Liu B, Kiyono T, Amemiya M, Tanaka K, Yoshida K, Sugimoto N, Ohshima T, Fujita M.
A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo.
Biochim Biophys Acta. 1850(9):1676-84. (2015)

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Matsumura Y, Ohbayashi I, Takahashi H, Kojima S, Ishibashi N, Keta S, Nakagawa A, Hayashi R, Saéz-Vásquez J, Echeverria M, Sugiyama M, Nakamura K, Machida C, Machida Y.
A genetic link between epigenetic repressor AS1-AS2 and a putative small subunit processome in leaf polarity establishment of Arabidopsis.
Biol Open. 5(7):942-54. (2016)

Miyasaka H, Ogata T, Tanaka S, Ohama T, Kano S, Kazuhiro F, Hayashi S, Yamamoto S, Takahashi H, Matsuura H, Hirata K.
Is chloroplastic class IIA aldolase a marine enzyme?
ISME J. (2016) in press

Takahashi H, Kaniwa N, Saito Y, Sai K, Hamaguchi T, Shirao K, Shimada Y, Matsumura Y, Ohtsu A, Yoshino T, Doi T, Takahashi A, Odaka Y, Okuyama M, Sawada J, Sakamoto H, Yoshida T.
Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method.
BMC Cancer.15:718. (2015)

Machida C, Nakagawa A, Kojima S, Takahashi H, Machida Y.
The complex of ASYMMETRIC LEAVES (AS) proteins plays a central role in antagonistic interactions of genes for leaf polarity specification in Arabidopsis.
Wiley Interdiscip Rev Dev Biol. 4(6):655-71. (2015)

Kumasaka MY, Yajima I, Iida M, Takahashi H, Inoue Y, Fukushima S, Ihn H, Takeda K, Naito Y, Yoshikawa T, Kato M.
Correlated expression levels of endothelin receptor B and Plexin C1 in melanoma.
Am J Cancer Res. 5(3):1117-23. (2015)

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Ohnishi H, Kawamoto N, Seishima M, Ohara O, Fukao T.
A Japanese family case with juvenile onset Behçet's disease caused by TNFAIP3 mutation.
Allergol Int. (2016) in press

Kato H, Matsuo M, Ozeki M, Fukao T.
Rebound adenoid hyperplasia after chemotherapy in pediatric patients with head and neck lymphoma: MR imaging findings.
Jpn J Radiol. 34(9):633-9. (2016)

Akagawa S, Fukao T, Akagawa Y, Sasai H, Kohdera U, Kino M, Shigematsu Y, Aoyama Y, Kaneko K.
Japanese Male Siblings with 2-Methyl-3-Hydroxybutyryl-CoA Dehydrogenase Deficiency (HSD10 Disease) Without Neurological Regression.
JIMD Rep. (2016) in press

Ohnishi H, Kawamoto N, Kaneko H, Kasahara K, Ohara O, Kato Z, Fukao T.
A case of selective IgG subclass deficiency with STAT3 mutation.
Allergol Int. (2016) in press

Yasuda E, Suzuki Y, Shimada T, Sawamoto K, Mackenzie WG, Theroux MC, Pizarro C, Xie L, Miller F, Rahman T, Kecskemethy HH, Nagao K, Morlet T, Shaffer TH, Chinen Y, Yabe H, Tanaka A, Shintaku H, Orii KE, Orii KO, Mason RW, Montaño AM, Fukao T, Orii T, Tomatsu S.
Activity of daily living for Morquio A syndrome.
Mol Genet Metab. 118(2):111-22. (2016)

Kato H, Ozeki M, Fukao T, Matsuo M.
Craniofacial CT findings of Gorham-Stout disease and generalized lymphatic anomaly.
Neuroradiology. 58(8):801-6. (2016)

Ozeki M, Nozawa A, Hori T, Kanda K, Kimura T, Kawamoto N, Fukao T.
Propranolol for infantile hemangioma: Effect on plasma vascular endothelial growth factor.
Pediatr Int. (2016) in press

Ozeki M, Hori T, Kanda K, Kawamoto N, Ibuka T, Miyazaki T, Fukao T.
Everolimus for Primary Intestinal Lymphangiectasia With Protein-Losing Enteropathy.
Pediatrics. (2016) in press

Matsumoto H, Ozeki M, Hori T, Kanda K, Kawamoto N, Nagano A, Azuma E, Miyazaki T, Fukao T.
Successful Everolimus Treatment of Kaposiform Hemangioendothelioma With Kasabach-Merritt Phenomenon: Clinical Efficacy and Adverse Effects of mTOR Inhibitor Therapy.
J Pediatr Hematol Oncol. (2016) in press

Ozeki M, Fujino A, Matsuoka K, Nosaka S, Kuroda T, Fukao T.
Clinical Features and Prognosis of Generalized Lymphatic Anomaly, Kaposiform Lymphangiomatosis, and Gorham-Stout Disease.
Pediatr Blood Cancer. 63(5):832-8. (2016)

Nozawa A, Ozeki M, Kuze B, Asano T, Matsuoka K, Fukao T.
Gorham-Stout Disease of the Skull Base With Hearing Loss: Dramatic Recovery and Antiangiogenic Therapy.
Pediatr Blood Cancer. 63(5):931-4. (2016)

Sasai H, Shimozawa N, Asano T, Kawamoto N, Yamamoto T, Kimura T, Kawamoto M, Matsui E, Fukao T.
Successive MRI Findings of Reversible Cerebral White Matter Lesions in a Patient with Cystathionine β-Synthase Deficiency.
Tohoku J Exp Med. 237(4):323-7. (2015)

Shikano H, Ohnishi H, Fukutomi H, Ito K, Morimoto M, Teramoto T, Aoki M, Nishihori T, Akeda Y, Oishi K, Fukao T.
Mondini dysplasia with recurrent bacterial meningitis caused by three different pathogens.
Pediatr Int. 57(6):1192-5. (2015)

Otsuka H, Ozeki M, Kanda K, Hori T, Kawamoto N, Saigo C, Kato H, Makita H, Shibata T, Fukao T.
Complete bone regeneration in hemophilic pseudotumor of the mandible.
Pediatr Int. 58(5):406-408. (2016)

Ozeki M, Fujino A, Matsuoka K, Nosaka S, Fukao T.
Lymphangiomatosis and Gorham-Stout disease.
Nihon Rinsho. 73(10):1777-88. (2015)

Djouadi F, Habarou F, Le Bachelier C, Ferdinandusse S, Schlemmer D, Benoist JF, Boutron A, Andresen BS, Visser G, de Lonlay P, Olpin S, Fukao T, Yamaguchi S, Strauss AW, Wanders RJ, Bastin J.
Mitochondrial trifunctional protein deficiency in human cultured fibroblasts: effects of bezafibrate.
J Inherit Metab Dis. 39(1):47-58. (2016)

Aoyama Y, Yamamoto T, Sakaguchi N, Ishige M, Tanaka T, Ichihara T, Ohara K, Kouzan H, Kinosada Y, Fukao T.
Application of multiplex ligation-dependent probe amplification, and identification of a heterozygous Alu-associated deletion and a uniparental disomy of chromosome 1 in two patients with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.
Int J Mol Med. 35(6):1554-60. (2015)

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Kawasoe Y, Tsurimoto T, Nakagawa T, Masukata H, Takahashi TS.
MutSα maintains the mismatch repair capability by inhibiting PCNA unloading.
Elife. 5. pii: e15155. (2016)

Tashiro S, Handa T, Matsuda A, Ban T, Takigawa T, Miyasato K, Ishii K, Kugou K, Ohta K, Hiraoka Y, Masukata H, Kanoh J.
Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.
Nat Commun. 7:10393. (2016)

Ruan K, Yamamoto TG, Asakawa H, Chikashige Y, Kimura H, Masukata H, Haraguchi T, Hiraoka Y.
Histone H4 acetylation required for chromatin decompaction during DNA replication.
Sci Rep. 5:12720. (2015)

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Kawasoe Y, Tsurimoto T, Nakagawa T, Masukata H, Takahashi TS.
MutSα maintains the mismatch repair capability by inhibiting PCNA unloading.
Elife. 5. pii: e15155. (2016)

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Aizawa M, Sugimoto N, Watanabe S, Yoshida K, Fujita M.
Nucleosome assembly and disassembly activity of GRWD1, a novel Cdt1-binding protein that promotes pre-replication complex formation.
Biochim Biophys Acta. 1863(11):2739-2748. (2016)

Sugimoto N, Maehara K, Yoshida K, Yasukouchi S, Osano S, Watanabe S, Aizawa M, Yugawa T, Kiyono T, Kurumizaka H, Ohkawa Y, Fujita M.
Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture.
Nucleic Acids Res. 43(12):5898-911. (2015)

Ohira M, Iwasaki Y, Tanaka C, Kuroki M, Matsuo N, Kitamura T, Yukuhiro M, Morimoto H, Pang N, Liu B, Kiyono T, Amemiya M, Tanaka K, Yoshida K, Sugimoto N, Ohshima T, Fujita M.
A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo.
Biochim Biophys Acta. 1850(9):1676-84. (2015)

▲　ページトップへ

Kawasoe Y, Tsurimoto T, Nakagawa T, Masukata H, Takahashi TS.
MutSα maintains the mismatch repair capability by inhibiting PCNA unloading.
Elife. 5. pii: e15155. (2016)

Yang CC, Suzuki M, Yamakawa S, Uno S, Ishii A, Yamazaki S, Fukatsu R, Fujisawa R, Sakimura K, Tsurimoto T, Masai H.
Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.
Nat Commun. 7:12135. (2016)

Hirota K, Tsuda M, Mohiuddin, Tsurimoto T, Cohen IS, Livneh Z, Kobayashi K, Narita T, Nishihara K, Murai J, Iwai S, Guilbaud G, Sale JE, Takeda S.
In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.
Nucleic Acids Res. 44(15):7242-50. (2016)

Kawakami H, Ohashi E, Tsurimoto T, Katayama T.
Rapid Purification and Characterization of Mutant Origin Recognition Complexes in Saccharomyces cerevisiae.
Front Microbiol. 7:521. (2016)

Okimoto H, Tanaka S, Araki H, Ohashi E, Tsurimoto T.
Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in Saccharomyces cerevisiae.
Genes Cells. 21(5):482-91.(2016)

Kawakami H, Ohashi E, Kanamoto S, Tsurimoto T, Katayama T.
Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues.
Sci Rep. 5:14929. (2015)

Le HP, Masuda Y, Tsurimoto T, Maki S, Katayama T, Furukohri A, Maki H.
Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork.
Genes Cells. 20(10):817-33. (2015)

Takeishi Y, Iwaya-Omi R, Ohashi E, Tsurimoto T.
Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding.
J Biol Chem. 290(32):19923-32. (2015)

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Nagpal H, Fukagawa T.
Kinetochore assembly and function through the cell cycle.
Chromosoma. (2016) in press

Dyomin AG, Koshel EI, Kiselev AM, Saifitdinova AF, Galkina SA, Fukagawa T, Kostareva AA, Gaginskaya ER.
Chicken rRNA Gene Cluster Structure.
PLoS One. 11(6):e0157464. (2016)

Nishino T, Fukagawa T.
Biochemical and Structural Analysis of Kinetochore Histone-Fold Complexes.
Methods Mol Biol. 1413:135-46. (2016)

Kusakabe M, Oku H, Matsuda R, Hori T, Muto A, Igarashi K, Fukagawa T, Harata M.
Genetic complementation analysis showed distinct contributions of the N-terminal tail of H2A.Z to epigenetic regulations.
Genes Cells. 21(2):122-35. (2016)

Wood L, Booth DG, Vargiu G, Ohta S, deLima Alves F, Samejima K, Fukagawa T, Rappsilber J, Earnshaw WC.
Auxin/AID versus conventional knockouts: distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability.
Open Biol. 6(1):150230. (2016)

Samejima I, Spanos C, Alves Fde L, Hori T, Perpelescu M, Zou J, Rappsilber J, Fukagawa T, Earnshaw WC.
Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore.
J Cell Biol. 211(6):1141-56. (2015)

Satrimafitrah P, Barman HK, Ahmad A, Nishitoh H, Nakayama T, Fukagawa T, Takami Y.
RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability.
Chromosome Res. 24(2):161-73. (2016)

Furuta M, Hori T, Fukagawa T.
Chromatin binding of RCC1 during mitosis is important for its nuclear localization in interphase.
Mol Biol Cell. 27(2):371-81. (2016)

Amakawa Y, Sakata Y, Hoki Y, Arata S, Shioda S, Fukagawa T, Sasaki H, Sado T.
A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.
Development. 142(24):4299-308. (2015)

Nagpal H, Hori T, Furukawa A, Sugase K, Osakabe A, Kurumizaka H, Fukagawa T.
Dynamic changes in CCAN organization through CENP-C during cell-cycle progression.
Mol Biol Cell. 26(21):3768-76. (2015)

Fukagawa T.
Cell Division: A New Role for the Kinetochore in Central Spindle Assembly.
Curr Biol. 25(13):R554-7. (2015)

Perpelescu M, Hori T, Toyoda A, Misu S, Monma N, Ikeo K, Obuse C, Fujiyama A, Fukagawa T.
HJURP is involved in the expansion of centromeric chromatin.
Mol Biol Cell. 26(15):2742-54. (2015)

▲　ページトップへ

Okimoto H, Tanaka S, Araki H, Ohashi E, Tsurimoto T.
Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in Saccharomyces cerevisiae.
Genes Cells. 21(5):482-91. (2016)

Tanaka S, Miyazawa-Onami M, Iida T, Araki H.
iAID: an improved auxin-inducible degron system for the construction of a 'tight' conditional mutant in the budding yeast Saccharomyces cerevisiae.
Yeast. 32(8):567-81. (2015)

▲　ページトップへ

Niki H, Yano K.
In vitro topological loading of bacterial condensin MukB on DNA, preferentially single-stranded DNA rather than double-stranded DNA.
Sci Rep. 6:29469. (2016)

Nakai R, Fujisawa T, Nakamura Y, Nishide H, Uchiyama I, Baba T, Toyoda A, Fujiyama A, Naganuma T, Niki H.
Complete Genome Sequence of Aurantimicrobium minutum Type Strain KNCT, a Planktonic Ultramicrobacterium Isolated from River Water.
Genome Announc. 4(3). pii: e00616-16. (2016)

Yano K, Masuda K, Akanuma G, Wada T, Matsumoto T, Shiwa Y, Ishige T, Yoshikawa H, Niki H, Inaoka T, Kawamura F.
Growth and sporulation defects in Bacillus subtilis mutants with a single rrn operon can be suppressed by amplification of the rrn operon.
Microbiology. 162(1):35-45. (2016)

Nakai R, Baba T, Niki H, Nishijima M, Naganuma T.
Aurantimicrobium minutum gen. nov., sp. nov., a novel ultramicrobacterium of the family Microbacteriaceae, isolated from river water.
Int J Syst Evol Microbiol. (2015) in press

Monteiro DC, Patel V, Bartlett CP, Nozaki S, Grant TD, Gowdy JA, Thompson GS, Kalverda AP, Snell EH, Niki H, Pearson AR, Webb ME.
The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A.
Chem Biol. 22(4):492-503. (2015)

Niki H.
Schizosaccharomyces japonicus: the fission yeast is a fusion of yeast and hyphae.
Yeast. 31(3):83-90. (2014)

▲　ページトップへ

Tanaka K, Hirota T.
Chromosomal instability: A common feature and a therapeutic target of cancer.
Biochim Biophys Acta. 1866(1):64-75. (2016)

Abe Y, Hirota T.
System-level deficiencies in Aurora B control in cancers.
Cell Cycle. (2016) in press

Nagasaka K, Hossain MJ, Roberti MJ, Ellenberg J, Hirota T.
Sister chromatid resolution is an intrinsic part of chromosome organization in prophase.
Nat Cell Biol. 18(6):692-9. (2016)

Takahashi M, Tanaka K, Wakai T, Hirota T.
Phosphoproteomic analysis of human mitotic chromosomes identified a chromokinesin KIF4A.
Biomed Res. 37(2):161-5. (2016)

Abe Y, Sako K, Takagaki K, Hirayama Y, Uchida KS, Herman JA, DeLuca JG, Hirota T.
HP1-Assisted Aurora B Kinase Activity Prevents Chromosome Segregation Errors.
Dev Cell. 36(5):487-97. (2016)

Minamino M, Ishibashi M, Nakato R, Akiyama K, Tanaka H, Kato Y, Negishi L, Hirota T, Sutani T, Bando M, Shirahige K.
Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.
Curr Biol. 25(13):1694-706. (2015)

Nagasaka K, Hirota T.
Clarifying the role of condensin in shaping chromosomes.
Nat Cell Biol. 17(6):711-3. (2015)

▲　ページトップへ

Wilson K, Park J, Curry TE Jr, Mishra B, Gossen J, Taniuchi I, Jo M.
Core Binding Factor-β Knockdown Alters Ovarian Gene Expression and Function in the Mouse.
Mol Endocrinol. 30(7):733-47. (2016)

Taniuchi I.
Views on helper/cytotoxic lineage choice from a bottom-up approach.
Immunol Rev. 271(1):98-113. (2016)

Tsuchiya Y, Naito T, Tenno M, Maruyama M, Koseki H, Taniuchi I, Naoe Y.
ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells.
J Leukoc Biol. 100(2):327-38. (2016)

Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, Ito K, Izumi S, Komori T.
Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development.
J Bone Miner Res. 31(7):1391-404. (2016)

Seo W, Taniuchi I.
Transcriptional regulation of early T-cell development in the thymus.
Eur J Immunol. 46(3):531-8. (2016)

Sakaguchi S, Hainberger D, Tizian C, Tanaka H, Okuda T, Taniuchi I, Ellmeier W.
MAZR and Runx Factors Synergistically Repress ThPOK during CD8+ T Cell Lineage Development.
J Immunol. 195(6):2879-87. (2015)

Almeida FF, Tenno M, Brzostek J, Li JL, Allies G, Hoeffel G, See P, Ng LG, Fehling HJ, Gascoigne NR, Taniuchi I, Ginhoux F.
Identification of a novel lymphoid population in the murine epidermis.
Sci Rep. 5:12554. (2015)

Park NR, Lim KE, Han MS, Che X, Park CY, Kim JE, Taniuchi I, Bae SC, Choi JY.
Core Binding Factor β Plays a Critical Role During Chondrocyte Differentiation.
J Cell Physiol. 231(1):162-71. (2016)

Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H.
Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse.
PLoS One. 10(5):e0127460. (2015)

Hao B, Naik AK, Watanabe A, Tanaka H, Chen L, Richards HW, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematsu T, Krangel MS.
An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
J Exp Med. 212(5):809-24. (2015)

▲　ページトップへ

Fujimoto A, Okada Y, Boroevich KA, Tsunoda T, Taniguchi H, Nakagawa H.
Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes.
Sci Rep. 6:26483. (2016)

Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Wardell CP, Hayami S, Nakamura T, Aikata H, Arihiro K, Boroevich KA, Abe T, Nakano K, Maejima K, Sasaki-Oku A, Ohsawa A, Shibuya T, Nakamura H, Hama N, Hosoda F, Arai Y, Ohashi S, Urushidate T, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Ojima H, Hiraoka N, Okusaka T, Kubo M, Marubashi S, Yamada T, Hirano S, Yamamoto M, Ohdan H, Shimada K, Ishikawa O, Yamaue H, Chayama K, Miyano S, Aburatani H, Shibata T, Nakagawa H.
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
Nat Genet. 48(5):500-9. (2016)

Alioto TS, Buchhalter I, Derdak S, Hutter B, Eldridge MD, Hovig E, Heisler LE, Beck TA, Simpson JT, Tonon L, Sertier AS, Patch AM, Jäger N, Ginsbach P, Drews R, Paramasivam N, Kabbe R, Chotewutmontri S, Diessl N, Previti C, Schmidt S, Brors B, Feuerbach L, Heinold M, Gröbner S, Korshunov A, Tarpey PS, Butler AP, Hinton J, Jones D, Menzies A, Raine K, Shepherd R, Stebbings L, Teague JW, Ribeca P, Giner FC, Beltran S, Raineri E, Dabad M, Heath SC, Gut M, Denroche RE, Harding NJ, Yamaguchi TN, Fujimoto A, Nakagawa H, Quesada V, Valdés-Mas R, Nakken S, Vodák D, Bower L, Lynch AG, Anderson CL, Waddell N, Pearson JV, Grimmond SM, Peto M, Spellman P, He M, Kandoth C, Lee S, Zhang J, Létourneau L, Ma S, Seth S, Torrents D, Xi L, Wheeler DA, López-Otín C, Campo E, Campbell PJ, Boutros PC, Puente XS, Gerhard DS, Pfister SM, McPherson JD, Hudson TJ, Schlesner M, Lichter P, Eils R, Jones DT, Gut IG.
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.
Nat Commun. 6:10001. (2015)

Shigemizu D, Aiba T, Nakagawa H, Ozaki K, Miya F, Satake W, Toda T, Miyamoto Y, Fujimoto A, Suzuki Y, Kubo M, Tsunoda T, Shimizu W, Tanaka T.
Exome Analyses of Long QT Syndrome Reveal Candidate Pathogenic Mutations in Calmodulin-Interacting Genes.
PLoS One. 10(7):e0130329. (2015)

▲　ページトップへ

Yang CC, Suzuki M, Yamakawa S, Uno S, Ishii A, Yamazaki S, Fukatsu R, Fujisawa R, Sakimura K, Tsurimoto T, Masai H.
Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.
Nat Commun. 7:12135. (2016)

Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K.
Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.
Nucleic Acids Res. (2016) in press

You Z, Ode KL, Shindo M, Takisawa H, Masai H.
Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.
Cell Cycle. 15(9):1213-26. (2016)

Tanaka T, Nishito Y, Masai H.
Fork restart protein, PriA, binds around oriC after depletion of nucleotide precursors: Replication fork arrest near the replication origin.
Biochem Biophys Res Commun. 470(3):546-51. (2016)

Tanaka H, Muto A, Shima H, Katoh Y, Sax N, Tajima S, Brydun A, Ikura T, Yoshizawa N, Masai H, Hoshikawa Y, Noda T, Nio M, Ochiai K, Igarashi K.
Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3.
J Biol Chem. 291(12):6316-30. (2016)

Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.
J Biol Chem. 291(11):5473-83. (2016)

Kanoh Y, Matsumoto S, Fukatsu R, Kakusho N, Kono N, Renard-Guillet C, Masuda K, Iida K, Nagasawa K, Shirahige K, Masai H.
Rif1 binds to G quadruplexes and suppresses replication over long distances.
Nat Struct Mol Biol. 22(11):889-97. (2015)

▲　ページトップへ

Ding DQ, Haraguchi T, Hiraoka Y.
A cohesin-based structural platform supporting homologous chromosome pairing in meiosis.
Curr Genet. 62(3):499-502. (2016)

Ding DQ, Matsuda A, Okamasa K, Nagahama Y, Haraguchi T, Hiraoka Y.
Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe.
Chromosoma. 125(2):205-14. (2016)

Matsuda A, Chikashige Y, Ding DQ, Ohtsuki C, Mori C, Asakawa H, Kimura H, Haraguchi T, Hiraoka Y.
Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast.
Nat Commun. 6:7753. (2015)

▲　ページトップへ

Kobayashi T
Ribosomal RNA gene repeats, their stability and cellular senescence
Proc Jpn Acad Ser B Phys Biol Sci. 90(4):119-29. (2014)

Fawcett JA, Iida T, Takuno S, Sugino RP, Kado T, Kugou K, Mura S, Kobayashi T, Ohta K, Nakayama J, Innan H.
Population Genomics of the Fission Yeast Schizosaccharomyces pombe.
PLoS One. 9(8):e104241 (2014)

▲　ページトップへ

Asada R, Takemata N, Hoffman CS, Ohta K, Hirota K.
Antagonistic controls of chromatin and mrna start site selection by Tup family corepressors and the CCAAT-binding factor.
Mol Cell Biol. 35(5):847-55. (2015).

Fawcett JA, Iida T, Takuno S, Sugino RP, Kado T, Kugou K, Mura S, Kobayashi T, Ohta K, Nakayama J, Innan H.
Population Genomics of the Fission Yeast Schizosaccharomyces pombe.
PLoS One. 9(8):e104241 (2014)

Kono H, Tamura M, Osada N, Suzuki H, Abe K, Moriwaki K, Ohta K, Shiroishi T.
Prdm9 polymorphism unveils mouse evolutionary tracks.
DNA Res. (3):315-26. (2014)

Ito M, Kugou K, Fawcett JA, Mura S, Ikeda S, Innan H, Ohta K.
Meiotic recombination cold spots in chromosomal cohesion sites.
Genes Cells. 19(5):359-73 (2014)

▲　ページトップへ

Tsujioka H, Kunieda T, Katou Y, Shirahige K, Kubo T.
Unique Gene Expression Profile of the Proliferating Xenopus Tadpole Tail Blastema Cells Deciphered by RNA-Sequencing Analysis.
PLoS One.10(3):e0111655. (2015)

Jeppsson K, Carlborg KK, Nakato R, Berta DG, Lilienthal I, Kanno T, Lindqvist A, Brink MC, Dantuma NP, Katou Y, Shirahige K, Sjögren C.
The chromosomal association of the smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.
PLoS Genet. 10(10):e1004680. (2014)

Takai H, Masuda K, Sato T, Sakaguchi Y, Suzuki T, Suzuki T, Koyama-Nasu R, Nasu-Nishimura Y, Katou Y, Ogawa H, Morishita Y, Kozuka-Hata H, Oyama M, Todo T, Ino Y, Mukasa A, Saito N, Toyoshima C, Shirahige K, Akiyama T.
5-Hydroxymethylcytosine Plays a Critical Role in Glioblastomagenesis by Recruiting the CHTOP-Methylosome Complex.
Cell Rep. 9(1):48-60. (2014)

Suda N, Itoh T, Nakato R, Shirakawa D, Bando M, Katou Y, Kataoka K, Shirahige K, Tickle C, Tanaka M.
Dimeric combinations of MafB, cFos and cJun control the apoptosis-survival balance in limb morphogenesis.
Development. 141(14):2885-94. (2014)

Komata M, Katou Y, Tanaka H, Nakato R, Shirahige K, Bando M.
Chromatin immunoprecipitation protocol for mammalian cells.
Methods Mol Biol. 1164:33-8. (2014)

Yata K, Bleuyard JY, Nakato R, Ralf C, Katou Y, Schwab RA, Niedzwiedz W, Shirahige K, Esashi F.
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
Cell Rep 7(5):1547-59. (2014)

▲　ページトップへ

Fawcett JA, Iida T, Takuno S, Sugino RP, Kado T, Kugou K, Mura S, Kobayashi T, Ohta K, Nakayama J, Innan H.
Population Genomics of the Fission Yeast Schizosaccharomyces pombe.
PLoS One. 9(8):e104241 (2014)

Tezuka A, Kasagi S, van Oosterhout C, McMullan M, Iwasaki WM, Kasai D, Yamamichi M, Innan H, Kawamura S, Kawata M.
Divergent selection for opsin gene variation in guppy (Poecilia reticulata) populations of Trinidad and Tobago.
Heredity (Edinb). 113(5):381-9. (2014)

Ito M, Kugou K, Fawcett JA, Mura S, Ikeda S, Innan H, Ohta K.
Meiotic recombination cold spots in chromosomal cohesion sites.
Genes Cells. 19(5):359-73 (2014)

▲　ページトップへ

Nishibuchi G, Machida S, Osakabe A, Murakoshi H, Hiragami-Hamada K, Nakagawa R, Fischle W, Nishimura Y, Kurumizaka H, Tagami H, Nakayama JI.
N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity.
Nucleic Acids Res. 42(20):12498-511 (2014)

Hountondji C, Bulygin K, Créchet JB, Woisard A, Tuffery P, Nakayama J, Frolova L, Nierhaus KH, Karpova G, Baouz S.
The CCA-end of P-tRNA Contacts Both the Human RPL36AL and the A-site Bound Translation Termination Factor eRF1 at the Peptidyl Transferase Center of the Human 80S Ribosome.
Open Biochem J. 8:52-67. (2014)

Nishibuchi G, Shibata Y, Hayakawa T, Hayakawa N, Ohtani Y, Shinmyozu K, Tagami H, Nakayama JI.
Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex.
J Biol Chem. 289(42):28956-70. (2014)

Fawcett JA, Iida T, Takuno S, Sugino RP, Kado T, Kugou K, Mura S, Kobayashi T, Ohta K, Nakayama J, Innan H.
Population Genomics of the Fission Yeast Schizosaccharomyces pombe.
PLoS One. 9(8):e104241 (2014)

Nishibuchi G, Nakayama J.
Biochemical and structural properties of heterochromatin protein 1: understanding its role in chromatin assembly.
J Biochem. 56(1):11-20. (2014)

▲　ページトップへ

Ariyoshi M, Otani J, Shirakawa M.
Structure Basis of Versatile Base Recognition of MBD4.
Yakugaku Zasshi. 135(1):3-9. (2015)

Morimoto D, Walinda E, Fukada H, Sou YS, Kageyama S, Hoshino M, Fujii T, Tsuchiya H, Saeki Y, Arita K, Ariyoshi M, Tochio H, Iwai K, Namba K, Komatsu M, Tanaka K, Shirakawa M.
The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.
Nat Commun. 6:6116. (2015)

Tsutsumi N, Kimura T, Arita K, Ariyoshi M, Ohnishi H, Yamamoto T, Zuo X, Maenaka K, Park EY, Kondo N, Shirakawa M, Tochio H, Kato Z.
The structural basis for receptor recognition of human interleukin-18.
Nat Commun. 5:5340. (2014)

Kimura T, Tsutsumi N, Arita K, Ariyoshi M, Ohnishi H, Kondo N, Shirakawa M, Kato Z, Tochio H.
Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes.
Acta Crystallogr F Struct Biol Commun. 70(Pt 10):1351-6. (2014)

▲　ページトップへ

Higo T, Suka N, Ehara H, Wakamori M, Sato S, Maeda H, Sekine S, Umehara T, Yokoyama S.
Development of a hexahistidine-3× FLAG-tandem affinity purification method for endogenous protein complexes in Pichia pastoris.
J Struct Funct Genomics. (4):191-9. (2014)

▲　ページトップへ

Takeuchi M, Matsuda K, Yamaguchi S, Asakawa K, Miyasaka N, Lal P, Yoshihara Y, Koga A, Kawakami K, Shimizu T, Hibi M.
Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry.
Dev Biol. 397(1):1-17. (2015)

Thapana W, Sujiwattanarat P, Srikulnath K, Hirai H, Koga A.
Reduction in the structural instability of cloned eukaryotic tandem-repeat DNA by low-temperature culturing of host bacteria.
Genet Res (Camb). 96:e13. (2014)

Baicharoen S, Miyabe-Nishiwaki T, Arsaithamkul V, Hirai Y, Duangsa-ard K, Siriaroonrat B, Domae H, Srikulnath K, Koga A, Hirai H.
Locational diversity of alpha satellite DNA and intergeneric hybridization aspects in the Nomascus and Hylobates genera of small apes.
PLoS One. 9(10):e109151. (2014)

Watanabe K, Koga H, Nakamura K, Fujita A, Hattori A, Matsuda M, Koga A.
Spontaneous germline excision of Tol1, a DNA-based transposable element naturally occurring in the medaka fish genome.
Genome. 57(4):193-9. (2014)

Koga A, Hirai Y, Terada S, Jahan I, Baicharoen S, Arsaithamkul V, Hirai H.
Evolutionary origin of higher-order repeat structure in alpha-satellite DNA of primate centromeres.
DNA Res. (4):407-15. (2014)

▲　ページトップへ

Yamaguchi K, Kajikawa M, Okada N.
Integrated mechanism for the generation of the 5' junctions of LINE inserts.
Nucleic Acids Res. 42(21):13269-79. (2014)

Hayashi Y, Kajikawa M, Matsumoto T, Okada N.
Mechanism by which a LINE protein recognizes its 3' tail RNA.
Nucleic Acids Res. 42(16):10605-17. (2014)

▲　ページトップへ

Kononenko AV, Lee NC, Liskovykh M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.
Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.
Nucleic Acids Res. 43(9):e57 (2015)

Ohzeki J, Larionov V, Earnshaw WC, Masumoto H.
Genetic and epigenetic regulation of centromeres: a look at HAC formation.
Chromosome Res. (1):87-103. (2015)

Hasegawa Y, Ishikura T, Hasegawa T, Watanabe T, Suzuki J, Nakayama M, Okamura Y, Okazaki T, Koseki H, Ohara O, Ikeno M, Masumoto H.
Generating a transgenic mouse line stably expressing human MHC surface antigen from a HAC carrying multiple genomic BACs.
Chromosoma. 124(1):107-18 (2015)

Kononenko AV, Bansal R, Lee NC, Grimes BR, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.
A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function.
Nucleic Acids Res. 42(21) (2014)

Erliandri I, Fu H, Nakano M, Kim JH, Miga KH, Liskovykh M, Earnshaw WC, Masumoto H, Kouprina N, Aladjem MI, Larionov V.
Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome.
Nucleic Acids Res.42(18):11502-16. (2014)

Obata Y, Furusawa Y, ....Masumoto H, ...Hase K.
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.
Nat Immunol. (6):571-9. (2014)

Kouprina N, Tomilin AN, Masumoto H, Earnshaw WC, Larionov V.
Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology.
Expert Opin Drug Deliv. (4):517-35 (2014)

▲　ページトップへ

Suzuki NM, Niwa A, Yabe M, Hira A, Okada C, Amano N, Watanabe A, Watanabe K, Heike T, Takata M, Nakahata T, Saito MK.
Pluripotent cell models of fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors.
Stem Cells Transl Med. 4(4):333-8. (2015)

Sato K, Ishiai M, Takata M, Kurumizaka H.
Defective FANCI binding by a fanconi anemia-related FANCD2 mutant.
PLoS One. 9(12):e114752. (2014)

Ishii K, Ishiai M, Morimoto H, Kanatsu-Shinohara M, Niwa O, Takata M, Shinohara T.
The Trp53-trp53inp1-tnfrsf10b pathway regulates the radiation response of mouse spermatogonial stem cells.
Stem Cell Reports. 3(4):676-89. (2014)

Takahashi D, Sato K, Shimomuki M, Takata M, Kurumizaka H.
Expression and purification of human FANCI and FANCD2 using Escherichia coli cells.
Protein Expr Purif. 103C:8-15. (2014)

Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L.
Modularized functions of the Fanconi anemia core complex.
Cell Rep. 7(6):1849-57. (2014)

Unno J, Itaya A, Taoka M, Sato K, Tomida J, Sakai W, Sugasawa K, Ishiai M, Ikura T, Isobe T, Kurumizaka H, Takata M.
FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair.
Cell Rep. 7(4):1039-47. (2014)

▲　ページトップへ

Iemura K, Tanaka K.
Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.
Nat Commun. 6:6447. (2015)

Amin MA, Itoh G, Iemura K, Ikeda M, Tanaka K.
CLIP-170 recruits PLK1 to kinetochores during early mitosis for chromosome alignment.
J Cell Sci. 127:2818-24.

▲　ページトップへ

Jo A, Mitani S, Shiba N, Hayashi Y, Hara Y, Takahashi H, Tsukimoto I, Tawa A, Horibe K, Tomizawa D, Taga T, Adachi S, Yoshida T, Ichikawa H.
High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML.
Leukemia. in press (2015)

Ebina I, Takemoto-Tsutsumi M, Watanabe S, Koyama H, Endo Y, Kimata K, Igarashi T, Murakami K, Kudo R, Ohsumi A, Noh AL, Takahashi H, Naito S, Onouchi H.
Identification of novel Arabidopsis thaliana upstream open reading frames that control expression of the main coding sequences in a peptide sequence-dependent manner.
Nucleic Acids Res. 43(3):1562-76. (2015)

Takahashi A, Nakayama R, Ishibashi N, Doi A, Ichinohe R, Ikuyo Y, Takahashi T, Marui S, Yasuhara K, Nakamura T, Sugita S, Sakamoto H, Yoshida T, Hasegawa T, Takahashi H.
Analysis of gene expression profiles of soft tissue sarcoma using a combination of knowledge-based filtering with integration of multiple statistics.
PLoS One. 4;9(9):e106801. (2014)

Takahashi H, Sai K, Saito Y, Kaniwa N, Matsumura Y, Hamaguchi T, Shimada Y, Ohtsu A, Yoshino T, Doi T, Okuda H, Ichinohe R, Takahashi A, Doi A, Odaka Y, Okuyama M, Saijo N, Sawada J, Sakamoto H, Yoshida T.
Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect.
PLoS One. 9(8):e105160. (2014)

▲　ページトップへ

Shimada T, Tomatsu S, Mason RW, Yasuda E, Mackenzie WG, Hossain J, Shibata Y, Montaño AM, Kubaski F, Giugliani R, Yamaguchi S, Suzuki Y, Orii KE, Fukao T, Orii T.
Di-sulfated Keratan Sulfate as a Novel Biomarker for Mucopolysaccharidosis II, IVA, and IVB.
JIMD Rep. 21:1-13 (2015)

Hori T1, Yamaguchi S, Shinkaku H, Horikawa R, Shigematsu Y, Takayanagi M, Fukao T.
Inborn errors of ketone body utilization.
Pediatr Int. 57(1):41-8. (2015)

Wang SP, Yang H, Wu JW, Gauthier N, Fukao T, Mitchell GA.
Metabolism as a tool for understanding human brain evolution: lipid energy metabolism as an example.
J Hum Evol. 77:41-9. (2014)

Kubota K, Ozeki M, Hori T, Kanda K, Funato M, Asano T, Fukao T, Kondo N.
Facial palsy as an unusual presenting symptom associated with acute myeloid leukemia.
Pediatr Int. 56(4):e37-40. (2014)

Fukao T, Akiba K, Goto M, Kuwayama N, Morita M, Hori T, Aoyama Y, Venkatesan R, Wierenga R, Moriyama Y, Hashimoto T, Usuda N, Murayama K, Ohtake A, Hasegawa Y, Shigematsu Y, Hasegawa Y.
The first case in Asia of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (HSD10 disease) with atypical presentation.
J Hum Genet. 59(11):609-14. (2014)

Shimada T, Kelly J, LaMarr WA, van Vlies N, Yasuda E, Mason RW, Mackenzie W, Kubaski F, Giugliani R, Chinen Y, Yamaguchi S, Suzuki Y, Orii KE, Fukao T, Orii T, Tomatsu S.
Novel heparan sulfate assay by using automated high-throughput mass spectrometry: Application to monitoring and screening for mucopolysaccharidoses.
Mol Genet Metab. 113(1-2):92-9. (2014)

Patel P, Suzuki Y, Tanaka A, Yabe H, Kato S, Shimada T, Mason RW, Orii KE, Fukao T, Orii T, Tomatsu S.
Impact of Enzyme Replacement Therapy and Hematopoietic Stem Cell Therapy on Growth in Patients with Hunter Syndrome.
Mol Genet Metab Rep. 1:184-196. (2014)

Fujisawa T, Fukao T, Shimomura Y, Seishima M.
A novel TRPS1 mutation in a family with tricho-rhino-phalangeal syndrome type 1.
J Dermatol. 41(6):514-7. (2014)

Mizuno Y, Kato G, Shu E, Ohnishi H, Fukao T, Ohara O, Fukumoto H, Katano H, Seishima M.
Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma in a Patient with Epidermodysplasia Verruciformis.
Acta Derm Venereol. (1):98-9. (2015)

▲　ページトップへ

Ruan K, Yamamoto TG, Asakawa H, Chikashige Y, Masukata H, Haraguchi T, Hiraoka Y.
Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway.
Genes Cells. 20(3):160-72. (2015)

▲　ページトップへ

Blaikley EJ, Tinline-Purvis H, Kasparek TR, Marguerat S, Sarkar S, Hulme L, Hussey S, Wee BY, Deegan RS, Walker CA, Pai CC, Bähler J, Nakagawa T, Humphrey TC.
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.
Nucleic Acids Res. 42(9):5644-56. (2014)

▲　ページトップへ

Hirota K, Yoshikiyo K, Guilbaud G, Tsurimoto T, Murai J, Tsuda M, Phillips LG, Narita T, Nishihara K, Kobayashi K, Yamada K, Nakamura J, Pommier Y, Lehmann A, Sale JE, Takeda S.
The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.
Nucleic Acids Res. 43(3):1671-83. (2015)

Ohashi E, Takeishi Y, Ueda S, Tsurimoto T.
Interaction between Rad9-Hus1-Rad1 and TopBP1 activates ATR-ATRIP and promotes TopBP1 recruitment to sites of UV-damage.
DNA Repair (Amst). 21:1-11. (2014)

Sun Q, Tsurimoto T, Juillard F, Li L, Li S, De León Vázquez E, Chen S, Kaye K.
Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence.
Proc Natl Acad Sci U S A. 111(32):11816-21. (2014)

▲　ページトップへ

Ohta S, Wood L, Toramoto I, Yagyu KI, Fukagawa T, Earnshaw WC.
CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly.
Mol Biol Cell. 26(7):1225-37 (2015)

Arimura Y, Shirayama K, Horikoshi N, Fujita R, Taguchi H, Kagawa W, Fukagawa T, Almouzni G, Kurumizaka H.
Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3.
Sci Rep. 4:7115. (2014)

Fukagawa T, Earnshaw WC.
The centromere: chromatin foundation for the kinetochore machinery.
Dev Cell. 30(5):496-508. (2014)

Hori T, Shang WH, Toyoda A, Misu S, Monma N, Ikeo K, Molina O, Vargiu G, Fujiyama A, Kimura H, Earnshaw WC, Fukagawa T.
Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly.
Dev Cell. 29(6):740-9. 2014

Nishibuchi I, Suzuki H, Kinomura A, Sun J, Liu NA, Horikoshi Y, Shima H, Kusakabe M, Harata M, Fukagawa T, Ikura T, Ishida T, Nagata Y, Tashiro S.
Reorganization of damaged chromatin by the exchange of histone variant H2A.Z-2.
Int J Radiat Oncol Biol Phys. 89(4):736-44. (2014)

Ishiguro K, Kim J, Shibuya H, Hernández-Hernández A, Suzuki A, Fukagawa T, Shioi G, Kiyonari H, Li XC, Schimenti J, Höög C, Watanabe Y.
Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.
Genes Dev. 28(6):594-607. (2014)

Fox D 3rd, Yan Z, Ling C, Zhao Y, Lee DY, Fukagawa T, Yang W, Wang W.
The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.
Cell Res. 24(5):560-75. (2014)

Kagawa N, Hori T, Hoki Y, Hosoya O, Tsutsui K, Saga Y, Sado T, Fukagawa T.
The CENP-O complex requirement varies among different cell types.
Chromosome Res. 22(3):293-303. (2014)

▲　ページトップへ

Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Yasmin N, Naoe Y, Bilic I, Moser MA, Hainberger D, Mayer H, Seiser C, Bergthaler A, Taniuchi I, Ellmeier W.J
A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
Leukoc Biol. 97(4):635-44. (2015)

Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, Iwama A.
Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.
Nat Commun. 5:5872. (2014)

Majumder K, Koues OI, Chan EA, Kyle KE, Horowitz JE, Yang-Iott K, Bassing CH, Taniuchi I, Krangel MS, Oltz EM.
Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.
J Exp Med. 212(1):107-20. (2015)

Islam MN, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto K, Kurosaka H, Honjo T, Kawanabe N, Kamioka H, Sakai T, Ishimaru N, Taniuchi I, Yamashiro T.
Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland.
Dev Dyn. 244(3):488-96. (2015)

Kobayashi M, Shelley WC, Seo W, Vemula S, Lin Y, Liu Y, Kapur R, Taniuchi I, Yoshimoto M.
Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development.
Proc Natl Acad Sci U S A. 111(33):12151-6. (2014)

Boucheron N, Tschismarov R, Goeschl L, Moser MA, Lagger S, Sakaguchi S, Winter M, Lenz F, Vitko D, Breitwieser FP, Müller L, Hassan H, Bennett KL, Colinge J, Schreiner W, Egawa T, Taniuchi I, Matthias P, Seiser C, Ellmeier W.
CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2.
Nat Immunol. 15(5):439-48. (2014)

▲　ページトップへ

Fujimoto A, Furuta M, …, Nakagawa H.
Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.
Nat Commun. 30;6:6120. (2015)

Shiraishi Y, Fujimoto A, …, Nakagawa H.
Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers.
PLoS One. 9(12):e114263. (2014)

Takezawa Y, Kato K, Oota H, Caulfield T, Fujimoto A, Honda S, Kamatani N, Kawamura S, Kawashima K, Kimura R, Matsumae H, Saito A, Savage PE, Seguchi N, Shimizu K, Terao S, Yamaguchi-Kabata Y, Yasukouchi A, Yoneda M, Tokunaga K.
Human genetic research, race, ethnicity and the labeling of populations: recommendations based on an interdisciplinary workshop in Japan.
BMC Med Ethics. 23;15:33. (2014)

▲　ページトップへ

Jeffery DC1, Kakusho N, You Z, Gharib M, Wyse B, Drury E, Weinreich M, Thibault P, Verreault A, Masai H, Yankulov K.
CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor I with chromatin.
Cell Cycle. 14(1):74-85. (2015)

Koiwai K, Kubota T, Watanabe N, Hori K, Koiwai O, Masai H.
Definition of the transcription factor TdIF1 consensus-binding sequence through genomewide mapping of its binding sites.
Genes Cells. 20(3):242-254. 8 (2015)

Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F.
NCOA4 transcriptional coactivator inhibits activation of DNA replication origins.
Mol Cell. 55(1):123-37. (2014)

Yoshizawa-Sugata N, Masai H.
Cell cycle synchronization and flow cytometry analysis of mammalian cells.
Methods Mol Biol. 1170:279-93. (2014)

Yamada M, Masai H, Bartek J.
Regulation and roles of Cdc7 kinase under replication stress.
Cell Cycle.13(12):1859-66. (2014)

Renard-Guillet C, Kanoh Y, Shirahige K, Masai H.
Temporal and spatial regulation of eukaryotic DNA replication: from regulated initiation to genome-scale timing program.
Semin Cell Dev Biol. 30:110-20. (2014)

▲　ページトップへ

Ganley AR, Kobayashi T.
Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging.
FEMS Yeast Res. in press (2013)

Saka K, Ide S, Ganley AR, Kobayashi T.
Cellular Senescence in Yeast Is Regulated by rDNA Noncoding Transcription.
Curr Biol. 23(18):1794-8. (2013)　 Press release

Ide S, Saka K, Kobayashi T.
Rtt109 prevents hyper-amplification of ribosomal RNA genes through histone modification in budding yeast
PLoS Genet. 9: e1003410. (2013)

▲　ページトップへ

Kurosawa K1, Lin W, Ohta K.
Chimeric antibodies.
Methods Mol Biol. 1060:139-48. (2014)

Yamada T, Ohta K.
Initiation of meiotic recombination in chromatin structure.
J Biochem. 154(2):107-14. (2013)

Galipon J, Miki A, Oda A, Inada T, Ohta K.
Stress-induced lncRNAs evade nuclear degradation and enter the translational machinery.
Genes Cells. 18(5):353-68. (2013)

Yamada S, Ohta K, Yamada T.
Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast.
Nucleic Acids Res. 41(6):3504-17 (2013)

▲　ページトップへ

Murakami-Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris JM, Ichikawa H, Kondo Y, Sekido Y, Shirahige K, Murakami H, Kadomatsu K.
Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.
Cell Cycle. 13(7):1115-31 (2014)

Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K, Ishii S.
Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells.
Cell Stem Cell.14(2):217-27. (2014)

Aramaki S, Hayashi K, Kurimoto K, Ohta H, Yabuta Y, Iwanari H, Mochizuki Y, Hamakubo T, Kato Y, Shirahige K, Saitou M.
A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.
Dev Cell. 27(5):516-29. (2013)

Natsume T1, Müller CA, Katou Y, Retkute R, Gierliński M, Araki H, Blow JJ, Shirahige K, Nieduszynski CA, Tanaka TU.
Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment.
Mol Cell. 50(5):661-74. (2013)

Chan KL, Gligoris T, Upcher W, Kato Y, Shirahige K, Nasmyth K, Beckouët F.
Pds5 promotes and protects cohesin acetylation.
Proc Natl Acad Sci U S A.110(32):13020-5. (2013)

Foltman M1, Evrin C, De Piccoli G, Jones RC, Edmondson RD, Katou Y, Nakato R, Shirahige K, Labib K.
Eukaryotic replisome components cooperate to process histones during chromosome replication.
Cell Rep. 3(3):892-904. (2013)

Enervald E, Lindgren E, Katou Y, Shirahige K, Ström L.
Importance of Polη for damage-induced cohesion reveals differential regulation of cohesion establishment at the break site and genome-wide.
PLoS Genet. 9(1):e1003158. (2013)

▲　ページトップへ

Fawcett JA, Kado T, Sasaki E, Takuno S, Yoshida K, Sugino RP, Kosugi S, Natsume S, Mitsuoka C, Uemura A, Takagi H, Abe A, Ishii T, Terauchi R, Innan H.
QTL Map Meets Population Genomics: An Application to Rice.
PLoS One. 8(12):e83720. (2013)

Kijima TE, Innan H.
Population Genetics and Molecular Evolution of DNA Sequences in Transposable Elements. I. A Simulation Framework.
Genetics. 195(3):957-67. (2013)

Ezawa K, Innan H.
Theoretical framework of population genetics with somatic mutations taken into account: application to copy number variations in humans.
Heredity (Edinb). Nov;111(5):364-74. (2013)

Fawcett JA, Innan H.
The role of gene conversion in preserving rearrangement hotspots in the human genome.
Trends Genet. 29(10):561-8. (2013)

Sasaki E, Sugino RP, Innan H.
The Linkage Method: A Novel Approach for SNP Detection and Haplotype Reconstruction from a Single Diploid Individual Using Next-Generation Sequence Data.
Mol Biol Evol. (9):2187-96 (2013)

Ezawa K, Innan H.
Competition Between the Sperm of a Single Male Can Increase the Evolutionary Rate of Haploid Expressed Genes.
Genetics. 194(3):709-19. (2013)

Kutsukake N, Innan H.
Simulation-based likelihood approach for evolutionary models of phenotypic traits on phylogeny.
Evolution. 67(2):355-67. (2013)

Takagi H, Abe A, Yoshida K, Kosugi S, Natsume S, Mitsuoka C, Uemura A, Utsushi H, Tamiru M, Takuno S, Innan H, Cano LM, Kamoun S, Terauchi R.
QTL-seq: rapid mapping of quantitative trait loci in rice by whole genome resequencing of DNA from two bulked populations.
Plant J. 74(1):174-83(2013)

▲　ページトップへ

Kato H, Okazaki K, Iida T, Nakayama J, Murakami Y, Urano T.
Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.
Sci Rep. 3:2186. (2013)

Mano Y, Kobayashi T, Nakayama J, Uchida H, Oki M
Correlation of Epigenetic Switching between Multiple Single Cell Visualization of Yeast Gene Expression Shows Heterochromatic Regions through Multiple Generations
PLOS Biol. (7):e1001601 (2013)

Kamata K, Hatanaka A, Goswami G, Shinmyozu K, Nakayama JI, Urano T, Hatashita M, Uchida H, Oki M.
C-terminus of the Sgf73 subunit of SAGA and SLIK is important for retention in the larger complex and for heterochromatin boundary function.
Genes cells., (9):823-37 (2013)

▲　ページトップへ

Terasaki N, Goodier JL, Cheung LE, Wang YJ, Kajikawa M, Kazazian HH Jr, Okada N.
In vitro screening for compounds that enhance human l1 mobilization.
PLoS One. 8(9):e74629 (2013)

▲　ページトップへ

Keyamura K, Sakaguchi C, Kubota Y, Niki H, Hishida T.
RecA recruits SMC-like RecN to DNA double-strand breaks.
J Biol Chem. 288(41):29229-37. (2013)

▲　ページトップへ

Dai X, Otake K, You C, Cai Q, Wang Z, Masumoto H, Wang Y.
Identification of Novel α-N-Methylation of CENP-B That Regulates Its Binding to the Centromeric DNA.
J Proteome Res. 12(9):4167-75. (2013)

Lee HS, Lee NC, Grimes BR, Samoshkin A, Kononenko AV, Bansal R, Masumoto H, Earnshaw WC, Kouprina N, Larionov V.
A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells.
BMC Cancer. 13:252 (2013)

Lee NC, Kononenko AV, Lee HS, Tolkunova EN, Liskovykh MA, Masumoto H, Earnshaw WC, Tomilin AN, Larionov V, Kouprina N.
Protecting a transgene expression from the HAC-based vector by different chromatin insulators.
Cell Mol Life Sci. 70(19):3723-37 (2013)

Kouprina N, Earnshaw WC, Masumoto H, Larionov V.
A new generation of human artificial chromosomes for functional genomics and gene therapy.
Cell Mol Life Sci. 70(7):1135-48. (2013)

▲　ページトップへ

Tarumoto Y, Kanoh J, Ishikawa F.
Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.
J Biol Chem. 288(26):19260-8 (2013)

Kanoh J.
Release of chromosomes from the nuclear envelope: a universal mechanism for eukaryotic mitosis?
Nucleus. 4(2):100-4 (2013)

Tashiro S, Asano T, Kanoh J, Ishikawa F.
Transcription-induced chromatin association of RNA surveillance factors mediates facultative heterochromatin formation in fission yeast.
Genes Cells. (4):327-39. (2013)

▲　ページトップへ

Motegi A, Takata M.
Multiple Genetic Manipulations of DT40 Cell Line.
Methods Mol Biol. 1114:25-35. (2014)

Hosono Y, Abe T, Ishiai M, Islam MN, Arakawa H, Wang W, Takeda S, Ishii Y, Takata M, Seki M, Enomoto T.
Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents.
Biochim Biophys Acta. 1843(5):1002-12. (2014)

Hira A, Yabe H, Yoshida K, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Nakamura J, Kojima S, Ogawa S, Matsuo K, Takata M, Yabe M.
Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.
Blood. 31;122(18):3206-9. (2013)　 Press release

Kobayashi M, Hayashi N, Takata M, Yamamoto K.
NBS1 directly activates ATR independently of MRE11 and TOPBP1.
Genes Cells. (3):238-46 (2013)

Tomida J, Itaya A, Shigechi T, Unno J, Uchida E, Ikura M, Masuda Y, Matsuda S, Adachi J, Kobayashi M, Meetei AR, Maehara Y, Yamamoto KI, Kamiya K, Matsuura A, Matsuda T, Ikura T, Ishiai M, Takata M.
A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.
Nucleic Acids Res. 41(14):6930-6941 (2013)

▲　ページトップへ

Itoh G, Sugino S, Ikeda M, Mizuguchi M, Kanno SI, Amin MA, Iemura K, Yasui A, Hirota T, Tanaka K.
The nucleoporin Nup188 is required for chromosome alignment in mitosis.
Cancer Sci. 104(7):871-9. (2013)

▲　ページトップへ

Ishiguro K, Kim J, Shibuya H, Hernández-Hernández A, Suzuki A, Fukagawa T, Shioi G, Kiyonari H, Li XC, Schimenti J, Höög C, Watanabe Y.
Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.
Genes Dev. 28(6):594-607. (2014)

Shibuya H, Ishiguro K, Watanabe Y.
The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.
Nat Cell Biol. 16(2):145-56. (2014)

Kim JH1, Ishiguro K, Kudo N, Watanabe Y.
Studying meiosis-specific cohesins in mouse embryonic oocytes.
Methods Mol Biol. 957:47-57. (2013)

▲　ページトップへ

Kawasaki Y, Lee J, Matsuzawa A, Kohda T, Kaneko-Ishino T, Ishino F.
Active DNA demethylation is required for complete imprint erasure in primordial germ cells.
Sci Rep.3;4:3658. (2014)

Kohda T.
Effects of embryonic manipulation and epigenetics.
J Hum Genet.58(7):416-20. (2013)

▲　ページトップへ

Fornander LH, Renodon-Cornière A, Kuwabara N, Ito K, Tsutsui Y, Shimizu T, Iwasaki H, Nordén B, Takahashi M.
Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament.
Nucleic Acids Res. 42(4):2358-65. (2014)

Murayama Y, Kurokawa Y, Tsutsui Y, Iwasaki H.
Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition.
Genes Dev. 27(21):2299-304. (2013)

▲　ページトップへ

Fukushima T, Kaneoka H, Yasuno T, Sasaguri Y, Tokuyasu T, Tokoro K, Fukao T, Saito T.
Three novel mutations in the carnitine-acylcarnitine translocase (CACT) gene in patients with CACT deficiency and in healthy individuals.
J Hum Genet. 58(12):788-93. (2013)

Fukao T, Aoyama Y, Murase K, Hori T, Harijan RK, Wierenga RK, Boneh A, Kondo N.
Development of MLPA for human ACAT1 gene and identification of a heterozygous Alu-mediated deletion of exons 3 and 4 in a patient with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.
Mol Genet Metab. (1-2):184-7. doi: 10. (2013)

▲　ページトップへ

Sabouri S, Kobayashi M, Begum NA, Xu J, Hirota K, Honjo T.
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion.
Proc Natl Acad Sci U S A. 111(6):2253-8. (2014)

Al Abo M, Dejsuphong D, Hirota K, Yonetani Y, Yamazoe M, Kurumizaka H, Takeda S.
Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1-PALB2-BRCA2 Complex.
Cancer Res.74(3):797-807. (2014)

Mohiuddin, Keka IS, Evans TJ, Hirota K, Shimizu H, Kono K, Takeda S, Hirano S.
A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes.
Arch Toxicol. 88(1):145-60. (2014)

Saito Y1, Takeda J, Okada M, Kobayashi J, Kato A, Hirota K, Taoka M, Matsumoto T, Komatsu K, Isobe T.
The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination.
Sci Rep. 3:2022. (2013)

Kikuchi K, Narita T, Pham VT, Iijima J, Hirota K, Keka IS, Mohiuddin, Okawa K, Hori T, Fukagawa T, Essers J, Kanaar R, Whitby MC, Sugasawa K, Taniguchi Y, Kitagawa K, Takeda S.
Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination.
Cancer Res. 73(14):4362-71. (2013)

Fujita M, Sasanuma H, Yamamoto KN, Harada H, Kurosawa A, Adachi N, Omura M, Hiraoka M, Takeda S, Hirota K.
Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks.
PLoS One. 8(4):e60043. (2013)

▲　ページトップへ

Niki H.
Schizosaccharomyces japonicus: the fission yeast is a fusion of yeast and hyphae.
Yeast. (3):83-90. (2014)

Keyamura K, Sakaguchi C, Kubota Y, Niki H, Hishida T.
RecA protein recruits structural maintenance of chromosomes (SMC)-like RecN protein to DNA double-strand breaks.
J Biol Chem. 288(41):29229-37. (2013)

Yano K, Wada T, Suzuki S, Tagami K, Matsumoto T, Shiwa Y, Ishige T, Kawaguchi Y, Masuda K, Akanuma G, Nanamiya H, Niki H, Yoshikawa H, Kawamura F.
Multiple rRNA operons are essential for efficient cell growth and sporulation as well as outgrowth in Bacillus subtilis.
Microbiology. 159(Pt 11):2225-36. (2013)

Shiomi D, Niki H.
A mutation in the promoter region of zipA, a component of the divisome, suppresses the shape defect of RodZ-deficient cells.
Microbiologyopen. (5):798-810. (2013)

Okamoto S, Furuya K, Nozaki S, Aoki K, Niki H.
Synchronous activation of cell division by light or temperature stimuli in the dimorphic yeast Schizosaccharomyces japonicus.
Eukaryot Cell. (9):1235-43. (2013)


Aoki K, Shiwa Y, Takada H, Yoshikawa H, Niki H.
Regulation of nuclear envelope dynamics via APC/C is necessary for the progression of semi-open mitosis in Schizosaccharomyces japonicus.
Genes Cells.(9):733-52. (2013)

▲　ページトップへ

Gallego-Paez LM, Tanaka H, Bando M, Takahashi M, Nozaki N, Nakato R, Shirahige K, Hirota T.
Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.
Mol Biol Cell. (2):302-17. (2014)

Ando K, Ozaki T, Hirota T, Nakagawara A.
NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint.
PLoS One. 8(12):e82744. (2013)

Itoh G, Sugino S, Ikeda M, Mizuguchi M, Kanno SI, Amin MA, Iemura K, Yasui A, Hirota T, Tanaka K.
The nucleoporin Nup188 is required for chromosome alignment in mitosis.
Cancer Sci. 104(7):871-9. (2013)

▲　ページトップへ

Sharif J, Endo TA, Ito S, Ohara O, Koseki H.
Embracing change to remain the same: conservation of polycomb functions despite divergence of binding motifs among species.
Curr Opin Cell Biol. (3):305-13. (2013)

▲　ページトップへ

Masai H.
ATM in prevention of genomic instability.
Cell Cycle. in press (2014)

Matsumoto S, Masai H.
Regulation of chromosome dynamics by Hsk1/Cdc7 kinase.
Biochem Soc Trans. 41(6):1712-9. (2013)

Yamada M, Watanabe K, Mistrik M, Vesela E, Protivankova I, Mailand N, Lee M, Masai H, Lukas J, Bartek J.
ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress.
Genes Dev. 27(22):2459-72. (2013)

You Z1, De Falco M, Kamada K, Pisani FM, Masai H.
The mini-chromosome maintenance (Mcm) complexes interact with DNA polymerase α-primase and stimulate its ability to synthesize RNA primers.
PLoS One. 8(8):e72408. (2013)

Jeffery DC, Wyse BA, Rehman MA, Brown GW, You Z, Oshidari R, Masai H, Yankulov KY.
Analysis of epigenetic stability and conversions in Saccharomyces cerevisiae reveals a novel role of CAF-I in position-effect variegation.
Nucleic Acids Res. 41(18):8475-88. (2013)

Yamazaki S, Hayano M, Masai H.
Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing.
Trends Genet. (8):449-60. (2013)

Masai H.
A personal reflection on the replicon theory: from R1 plasmid to replication timing regulation in human cells.
J Mol Biol. 425(23):4663-72. (2013)

Aria V, De Felice M, Di Perna R, Uno S, Masai H, Syvaoja JE, van Loon B, Hubscher U, Pisani FM.
The Human Tim/Tipin Complex Directly Interacts with DNA Polymerase {epsilon} and Stimulates its Synthetic Activity.
J Biol Chem. 288(18):12742-52. (2013)

▲　ページトップへ

Ding DQ, Haraguchi T, Hiraoka Y.
The role of chromosomal retention of noncoding RNA in meiosis.
Chromosome Res. (6-7):665-72. (2013)

▲　ページトップへ

Iida T, Iida N, Tsutsui Y, Yamao F, Kobayashi T.
RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast.
BBRC. 427, 143-7 (2012)

Poole AM, Kobayashi T, Ganley AR.
A positive role for yeast extrachromosomal rDNA circles?
Bioessays. 34, 725-9 (2012)

Ganley AR, Breitenbach M, Kennedy BK, Kobayashi T.
Yeast hypertrophy: cause or consequence of aging? Reply to Bilinski et al
FEMS Yeast Res. 12, 267-8 (2012)

▲　ページトップへ

Miyoshi T, Ito M, Ohta K.
Spatiotemporal regulation of meiotic recombination by Liaisonin.
Bioarchitecture. 3(1):20-4. (2013)

Miyoshi T, Ito M, Kugou K, Yamada S, Furuichi M, Oda A, Yamada T, Hirota K, Masai H, Ohta K.
A Central Coupler for Recombination Initiation Linking Chromosome Architecture to S Phase Checkpoint.
Mol. Cell. 47, 722-33 (2012)

▲　ページトップへ

Foltman M, Evrin C, De Piccoli G, Jones RC, Edmondson RD, Katou Y, Nakato R, Shirahige K, Labib K.
Eukaryotic replisome components cooperate to process histones during chromosome replication.
Cell Rep. 28;3(3):892-904. (2013)

Enervald E, Lindgren E, Katou Y, Shirahige K, Ström L.
Importance of polη for damage-induced cohesion reveals differential regulation of cohesion establishment at the break site and genome-wide.
PLoS Genet. 9(1), e1003158. (2013)

Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T. et al.,
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Nature. 489, 313-7 (2012)

De Piccoli G, Katou Y, Itoh T, Nakato R, Shirahige K, Labib K.
Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases.
Mol Cell. 45, 696-704 (2012)

▲　ページトップへ

Kutsukake N, Innan H.
Simulation-based likelihood approach for evolutionary models of phenotypic traits on phylogeny.
Evolution. 67(2):355-67 (2013)

Takuno S, Terauchi R, Innan H.
The Power of QTL Mapping with RILs.
PLoS One. 7(10), e46545 (2012)

Brunet F, Innan H, Liao BY, Wang W.
Molecular evolutionary routes that lead to innovations.
Int J Evol Biol.2012:483176 (2012)

Akita T, Takuno S, Innan H.
Modeling evolutionary growth of a microRNA-mediated regulation system.
J Theor Biol. 311, 54-65 (2012)

Abe A, Kosugi S, Yoshida K, Natsume S, Takagi H, Kanzaki H, Matsumura H, Yoshida K, Mitsuoka C, Tamiru M, Innan H, Cano L, Kamoun S, Terauchi R.
Genome sequencing reveals agronomically important loci in rice using MutMap.
Nat Biotechnol. 30, 174-8 (2012)

Yamamichi M, Innan H.
Estimating the migration rate from genetic variation data.
Heredity (Edinb) 108, 362-3 (2012)

▲　ページトップへ

Kawakami K, Hayashi A, Nakayama J, Murakami, Y.
A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA.
Genes Dev. 26, 1811-24 (2012)

Ishida M, Shimojo H, Hayashi A, Kawaguchi R, Ohtani Y, Uegaki K, Nishimura Y, Nakayama J.
Intrinsic Nucleic Acid-Binding Activity of Chp1 Chromodomain Is Required for Heterochromatic Gene Silencing.
Mol. Cell 47, 228-41 (2012)

Shiomi Y, Hayashi A, Ishii T, Shinmyozu K, Nakayama J, Sugasawa K, Nishitani H.
Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.
Mol Cell Biol. 32, 2279-88 (2012)

Hayashi A, Ishida M, Kawaguchi R, Urano T, Murakami Y, Nakayama J.
Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.
Proc Natl Acad Sci U S A. 109, 6159-64 (2012)

▲　ページトップへ

Takaoka Y, Kioi Y, Morito A, Otani J, Arita K, Ashihara E, Ariyoshi M, Tochio H, Shirakawa M, Hamachi I.
Quantitative comparison of protein dynamics in live cells and in vitro by in-cell (19)F-NMR.
Chem Commun (Camb). 49(27):2801-3. (2013)

Otani J, Arita K, Kato T, Kinoshita M, Kimura H, Suetake I, Tajima S, Ariyoshi M, Shirakawa M.
Structural basis of the versatile DNA recognition ability of the methyl CpG binding domain of methyl-CpG binding domain protein 4.
J Biol Chem. 288(9):6351-62 (2013)

Arita K, Isogai S, Oda T, Unoki M, Sugita K, Sekiyama N, Kuwata K, Hamamoto R, Tochio H, Sato M, Ariyoshi M, Shirakawa M.
Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.
Proc Natl Acad Sci U S A. 109, 12950-5 (2012)

Sekiyama N, Jee J, Isogai S, Akagi K, Huang TH, Ariyoshi M, Tochio H, Shirakawa M.
NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80.
J Biomol NMR 52, 339-50 (2012)

▲　ページトップへ

Kajikawa M, Sugano T, Sakurai R, Okada N.
Low dependency of retrotransposition on the ORF1 protein of the zebrafish LINE, ZfL2-1.
Gene 499, 41-7 (2012)

▲　ページトップへ

Masuda Y, Suzuki M, Kawai H, Hishiki A, Hashimoto H, Masutani C, Hishida T, Suzuki F, Kamiya K.
En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2-E3 pairs.
Nucleic Acids Res. 40(20), 10394-10407 (2012)

Haruta N, Kubota Y, Hishida T.
Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells.
Nucleic Acids Res. 40(17), 8406-15 (2012)

▲　ページトップへ

Tachiwana H, Miya Y, Shono N, Ohzeki JI, Osakabe A, Otake K, Larionov V, Earnshaw WC, Kimura H, Masumoto H, Kurumizaka H.
Nap1 regulates proper CENP-B binding to nucleosomes.
Nucleic Acids Res. 41(5):2869-2880 (2013)

Kouprina N, Samoshkin A, Erliandri I, Nakano M, Lee HS, Fu H, Iida Y, Aladjem M, Oshimura M, Masumoto H, Earnshaw WC, Larionov V.
Organization of Synthetic Alphoid DNA Array in Human Artificial Chromosome (HAC) with a Conditional Centromere.
ACS Synth Biol. 1(12):590-601 (2012)

Gross S, Catez F, Masumoto H, Lomonte P.
Centromere architecture breakdown induced by the viral E3 ubiquitin ligase ICP0 protein of herpes simplex virus type 1.
PLoS One. 7(9), e44227 (2012)

Bergmann JH, Martins NM, Larionov V, Masumoto H, Earnshaw WC.
HACking the centromere chromatin code: insights from human artificial chromosomes.
Chromosome Res. 20, 505-19 (2012)

Ohzeki JI, Bergmann JH, Kouprina N, Noskov VN, Nakano M, Kimura H, Earnshaw WC, Larionov V,Masumoto H.
Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly.
EMBO J. 31, 2391-402 (2012)

▲　ページトップへ

Kanoh J.
Release of chromosomes from the nuclear envelope: A universal mechanism for eukaryotic mitosis?
Nucleus. 4(2):100-4. (2013)

Fujita I, Tanaka M, Kanoh J.
Identification of the Functional Domains of the Telomere Protein Rap1 in Schizosaccharomyces pombe.
PLoS One. 7(11), e4915 (2012)

Fujita I, Nishihara Y, Tanaka M, Tsujii H, Chikashige Y, Watanabe Y, Saito M, Ishikawa F, Hiraoka Y, Kanoh J.
Telomere-Nuclear Envelope Dissociation Promoted by Rap1 Phosphorylation Ensures Faithful Chromosome Segregation.
Curr Biol. 22(20), 1932-7 (2012)

▲　ページトップへ

Kobayashi M, Hayashi N, Takata M, Yamamoto K.
NBS1 directly activates ATR independently of MRE11 and TOPBP1.
Genes Cells. (3):238-46. (2013)

Minami D, Takigawa N, Takeda H, Takata M, Ochi N, Ichihara E, Hisamoto A, Hotta K, Tanimoto M, Kiura K.
Synergistic effect of olaparib with combination of cisplatin on PTEN-deficient lung cancer cells.
Mol Cancer Res. 2013 (2):140-8.

Sato K, Ishiai M, Toda K, Furukoshi S, Osakabe A, Tachiwana H, Takizawa Y, Kagawa W, Kitao H, Dohmae N, Obuse C, Kimura H, Takata M, Kurumizaka H.
Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair.
EMBO J. 21, 3524-36 (2012)

Nishimura K, Ishiai M, Horikawa K, Fukagawa T, Takata M, Takisawa H, Kanemaki MT.
Mcm8 and Mcm9 Form a Complex that Functions in Homologous Recombination Repair Induced by DNA Interstrand Crosslinks.
Mol Cell. 47, 511-22 (2012)

Yan Z, Guo R, Paramasivam M, Shen W, Ling C, Fox D 3rd, Wang Y, Oostra AB, Kuehl J, Lee DY,Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Li L, Seidman MM, Wang W.
A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network.
Mol Cell. 47, 61-75 (2012)

Yabe M, Shimizu T, Morimoto T, Koike T, Takakura H, Tsukamoto H, Muroi K, Oshima K, Asami K, Takata M, Yamashita T, Kato S, Yabe H.
Matched sibling donor stem cell transplantation for Fanconi anemia patients with T-cell somatic mosaicism.
Pediatr Transplant. 16, 340-5 (2012)

Sato K, Toda K, Ishiai M, Takata M, Kurumizaka H.
DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI.
Nucleic Acids Res. 40, 4553-61 (2012)

Ishiai M, Uchida E, Takata M.
Establishment of the DNA repair-defective mutants in DT40 cells.
Methods Mol Biol. 920, 39-49 (2012)

▲　ページトップへ

Ueno K, Mineta K, Ito K, Endo T.
Exploring functionally related enzymes using radially distributed properties of active sites around the reacting points of bound ligands.
BMC Struct Biol. 26,12-5 (2012)

▲　ページトップへ

Tanaka K.
Dynamic regulation of kinetochore-microtubule interaction during mitosis.
J Biochem. 152(5), 415-24 (2012)

Tanaka K.
Regulatory mechanisms of kinetochore-microtubule interaction in mitosis.
Cell Mol Life Sci. 70(4):559-79 (2012)

▲　ページトップへ

Kim JH, Ishiguro K, Kudo N, Watanabe Y.
Studying meiosis-specific cohesins in mouse embryonic oocytes.
Methods Mol Biol. 957, 47-57 (2013)

Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y.
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
J Cell Biol. 23, 165-72 (2012)

▲　ページトップへ

Wakayama S, Kohda T, Obokata H, Tokoro M, Li C, Terashita Y, Mizutani E, Nguyen VT, Kishigami S, Ishino F, Wakayama T.
Successful Serial Recloning in the Mouse over Multiple Generations.
Cell Stem Cell. 12(3):293-7 (2013)

Kohda T, Ishino F.
Embryo manipulation via assisted reproductive technology and epigenetic asymmetry in mammalian early development.
Philos Trans R Soc Lond B Biol Sci. 368(1609), 20120353 (2013)

▲　ページトップへ

Iida T, Iida N, Tsutsui Y, Yamao F, Kobayashi T.
RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast.
BBRC. 427, 143-7 (2012)

▲　ページトップへ

Hori T, Fukao T, Murase K, Sakaguchi N, Harding CO, Kondo N.
Molecular Basis of Two-Exon Skipping (Exons 12 and 13) by c.1248+5g>a in OXCT1 Gene: Study on Intermediates of OXCT1 Transcripts in Fibroblasts.
Hum Mutat. 34(3):473-80. (2012)

Ozeki M, Kanda K, Kawamoto N, Ohnishi H, Fujino A, Hirayama M, Kato Z, Azuma E, Fukao T, Kondo N.
Propranolol as an alternative treatment option for pediatric lymphatic malformation.
Tohoku J Exp Med. 229(1), 61-6 (2013)

Funato M, Fukao T, Sasai H, Hori T, Terazawa D, Kanda K, Ozeki M, Mizuta K, Hirose Y, Kaneko H, Kondo N.
Paclitaxel-based chemotherapy for aggressive kaposiform hemangioendothelioma of the temporomastoid region: Case report and review of the literature.
Head Neck. in press (2012)

Teramoto T, Matsui E, Fukao T, Sakai K, Yonezawa H, Kato Z, Ohnishi H, Kaneko H, Kondo N, Azuma J, Nishima S.
Repeated-Dose Pharmacokinetics of Inhaled Ciclesonide (CIC-HFA) in Japanese Children with Bronchial Asthma: A Phase I Study.
Allergol Int. 61(4), 619-24 (2012)

Hori T, Ohnishi H, Teramoto T, Tsubouchi K, Naiki T, Hirose Y, Ohara O, Seishima M, Kaneko H, Fukao T, Kondo N.
Autosomal-Dominant Chronic Mucocutaneous Candidiasis with STAT1-Mutation can be Complicated with Chronic Active Hepatitis and Hypothyroidism.
J Clin Immunol. 32(6):1213-20 (2012)

▲　ページトップへ

Miyoshi T, Ito M, Kugou K, Yamada S, Furuichi M, Oda A, Yamada T, Hirota K, Masai H, Ohta K.
A Central Coupler for Recombination Initiation Linking Chromosome Architecture to S Phase Checkpoint.
Mol. Cell. 47, 722-33 (2012)

▲　ページトップへ

Hayashi K, Ogushi S, Kurimoto K, Shimamoto S, Ohta H, Saitou M.
Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice.
Science. 338(6109), 971-5 (2012)

▲　ページトップへ

Nanbu T, Takahashi K, Murray JM, Hirata N, Ukimori S, Kanke M, Masukata H, Yukawa M, Tsuchiya E, Ueno M.
Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes.
Mol Cell Biol. 33(6):1175-87 (2013)


Tazumi A, Masukata H.
Telomere-binding proteins play roles in control of replication timing.
Cell Cycle. 11(24), (2012)

Atsutoshi Tazumi, Masayoshi Fukuura, Ryuichiro Nakato, Ami Kishimoto, Tomokazu Takenaka, Shiho Ogawa, Ji-hoon Song, Tatsuro S. Takahashi, Takuro Nakagawa, Katsuhiko Shirahige, and Hisao Masukata
Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast
Genes Dev. 26, 2050-62 (2012)

Handa T, Kanke M, Takahashi TS, Nakagawa T, Masukata H.
DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast.
Mol Biol Cell. 23, 3240-53 (2012)

Higashi TL, Ikeda M, Tanaka H, Nakagawa T, Bando M, Shirahige K, Kubota Y, Takisawa H, Masukata H, Takahashi TS.
The prereplication complex recruits XEco2 to chromatin to promote cohesin acetylation in Xenopus egg extracts.
Curr Biol. 5;22, 977-88 (2012)

▲　ページトップへ

Shiomi D, Toyoda A, Aizu T, Ejima F, Fujiyama A, Shini T, Kohara Y, Niki H.
Mutations in cell elongation genes mreB, mrdA and mrdB suppress the shape defect of RodZ-deficient cells.
Mol Microbiol. 87(5):1029-44. (2013)

Gray AN, Henderson-Frost JM, Boyd D, Sharafi S, Niki H, Goldberg MB.
Unbalanced Charge Distribution as a Determinant for Dependence of a Subset of Escherichia coli Membrane Proteins on the Membrane Insertase YidC.
MBio. 3(6), e00500-12 (2012)

Nozaki S, Webb ME, Niki H.
An activator for pyruvoyl-dependent l-aspartate α-decarboxylase is conserved in a small group of the γ-proteobacteria including Escherichia coli.
Microbiologyopen. 1(3), 298-310 (2012)

Furuya K, Niki H.
Hyphal differentiation induced via a DNA damage checkpoint-dependent pathway engaged in crosstalk with nutrient stress signaling in Schizosaccharomyces japonicus.
Curr Genet. 58(5-6), 291-303. (2012)

Monteiro DC, Rugen MD, Shepherd D, Nozaki S, Niki H, Webb ME.
Formation of a heterooctameric complex between aspartate α-decarboxylase and its cognate activating factor, PanZ, is CoA-dependent.
BBRC. 426(3), 350-5. (2012)

Furuya K, Aoki K, Niki H.
Construction of an insertion marker collection of Sz. japonicus (IMACS) for genetic mapping and a fosmid library covering its genome.
Yeast. 29, 241-9 (2012)

▲　ページトップへ

Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T. et al.,
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Nature. 489, 313-7 (2012)

Shindo N, Kumada K, Hirota T.
Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.
Dev Cell. 17, 112-23 (2012)

▲　ページトップへ

Seong KH, Maekawa T, Ishii S.
Inheritance and memory of stress-induced epigenome change: roles played by the ATF-2 family of transcription factors.
Genes Cells.17, 249-63 (2012)

▲　ページトップへ

Suzuki T, Tsuzuku J, Hayashi A, Shiomi Y, Iwanari H, Mochizuki Y, Hamakubo T, Kodama T, Nishitani H, Masai H, Yamamoto T.
Inhibition of DNA Damage-induced Apoptosis through Cdc7-mediated Stabilization of Tob.
J Biol Chem. 287(48), 40256-65. (2012)

Miyoshi T, Ito M, Kugou K, Yamada S, Furuichi M, Oda A, Yamada T, Hirota K, Masai H, Ohta K.
A Central Coupler for Recombination Initiation Linking Chromosome Architecture to S Phase Checkpoint.
Mol. Cell. 47, 722-33 (2012)

Oda M, Kanoh Y, Watanabe Y, Masai H.
Regulation of DNA Replication Timing on Human Chromosome by a Cell-Type Specific DNA Binding Protein SATB1.
PLoS One. 7, e42375 (2012)

Yamazaki S, Ishii A, Kanoh Y, Oda M, Nishito Y, Masai H.
Rif1 regulates the replication timing domains on the human genome.
EMBO J. 31 3667-77 (2012)

Uno S, You Z, Masai H.
Purification of replication factors using insect and mammalian cell expression systems.
Methods. 57 214-21 (2012)

Moriyama K, Yoshizawa-Sugata N, Obuse C, Tsurimoto T, Masai H.
Epstein-Barr Nuclear Antigen 1 (EBNA1)-dependent Recruitment of Origin Recognition Complex (Orc) on oriP of Epstein-Barr Virus with Purified Proteins: STIMULATION BY Cdc6 THROUGH ITS DIRECT INTERACTION WITH EBNA1.
J Biol Chem. 6;287, 23977-94 (2012)

Barkley LR, Palle K, Durando M, Day TA, Gurkar A, Kakusho N, Li J, Masai H, Vaziri C.
c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks.
Mol Biol Cell. 23, 1943-54 (2012)

Ito S, Ishii A, Kakusho N, Taniyama C, Yamazaki S, Fukatsu R, Sakaue-Sawano A, Miyawaki A, Masai H.
Mechanism of cancer cell death induced by depletion of an essential replication regulator.
PLoS One. 7, e36372 (2012)

▲　ページトップへ

Ding DQ, Haraguchi T, Hiraoka Y.
Chromosomally-retained RNA mediates homologous pairing.
Nucleus. 3(6), 516-9 (2012)

Yamashita A, Shichino Y, Tanaka H, Hiriart E, Touat-Todeschini L, Vavasseur A, Ding DQ, Hiraoka Y, Verdel A, Yamamoto M.
Hexanucleotide motifs mediate recruitment of the RNA elimination machinery to silent meiotic genes.
Open Biol. 2,120014 (2012)

Ding DQ, Okamasa K, Yamane M, Tsutsumi C, Haraguchi T, Yamamoto M, Hiraoka Y.
Meiosis-specific noncoding RNA mediates robust pairing of homologous chromosomes in meiosis.
Science. 11, 732-6 (2012)

▲　ページトップへ

Kobayashi, T
How does genome instability affect lifespan?: roles of rDNA and telomeres.
Genes Cells. 16, 617-24 (2011)


Ganley AR, Kobayashi T.
Monitoring the Rate and Dynamics of Concerted Evolution in the Ribosomal DNA Repeats of Saccharomyces cerevisiae Using Experimental Evolution.
Mol Biol Evol. 28, 2883-91 (2011)


Miyazaki T, Kobayashi T.
Visualization of the dynamic behavior of ribosomal RNA gene repeats in living yeast cells.
Genes Cells. 16, 491-502 (2011)

▲　ページトップへ

Tanaka S, Nakato R, Katou Y, Shirahige K, Araki H
Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing.
Curr Biol. 21, 2055-63(2011)


Duong CT, Strack L, Futschik M, Katou Y, Nakao Y, Fujimura T, Shirahige K, Kodama Y, Nevoigt E.
Identification of Sc-type ILV6 as a target to reduce diacetyl formation in lager brewers' yeast.
Metab Eng. 13, 638-47 (2011)


Bermejo R, Capra T, Jossen R, Colosio A, Frattini C, Carotenuto W, Cocito A, Doksani Y, Klein H, Gómez-González B, Aguilera A, Katou Y, Shirahige K, Foiani M.
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.
Cell 146, 233-26 (2011)

▲　ページトップへ

Abe A, Kosugi S, Yoshida K, Natsume S, Takagi H, Kanzaki H, Matsumura H, Yoshida K, Mitsuoka C, Tamiru M, Innan H, Cano L, Kamoun S, Terauchi R.
Genome sequencing reveals agronomically important loci in rice using MutMap.
Nat Biotechnol. 30, 174-8 (2012)


Teshima KM, Innan H.
The coalescent with selection on copy number variants.
Genetics 190, 1077-86 (2012)


Yamamichi M, Gojobori J, Innan H.
An autosomal analysis gives no genetic evidence for complex speciation of humans and chimpanzees.
Mol Biol Evol. 29, 145-56 (2012)


Takuno S, Kado T, Sugino RP, Nakhleh L, Innan H
Population genomics in Bacteria: A case study of Staphylococcus aureus.
Mol Biol Evol. 29, 797-809 (2012)


Asano K, Yamasaki M, Takuno S, Miura K, Katagiri S, Ito T, Doi K, Wu J, Ebana K, Matsumoto T,Innan H, Kitano H, Ashikari M, Matsuoka M.
Artificial selection for a green revolution gene during japonica rice domestication.
Proc Natl Acad Sci U S A. 108, 11034-9 (2011)


Kitao H, Nanda I, Sugino RP, Kinomura A, Yamazoe M, Arakawa H, Schmid M, Innan H, Hiom K,Takata M.
FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells.
Genes Cells. 16, 714-27 (2011)


Sugino RP, Innan H.
Natural selection on gene order in the genome re-organization process after whole genome duplication of yeast.
Mol Biol Evol. 29, 71-9 (2011)


Takuno S, Innan H.
Selection fine tunes the expression of microRNA target genes in Arabidopsis thaliana.
Mol Biol Evol. 28, 2429-34 (2011)

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Hatanaka A., Chen B., Sun J.Q., Mano Y., Funakoshi M., Kobayashi H., Ju Y., Mizutani T., Shinmyozu K., Nakayama J., Miyamoto K., Uchida H. Oki M.
Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex.
Genes & Genetic Systems. 86, 305-14 (2011)


Goto, D.B., Nakayama, J.
RNA and epigenetic silencing: Insight from fission yeast.
Dev Growth Differ. 54, 129-41 (2011)


Kitano E, Hayashi A, Kanai D, Shinmyozu K, Nakayama J.
Roles of fission yeast Grc3 protein in ribosomal RNA processing and heterochromatic gene silencing.
J Biol Chem. 286, 15391-402 (2011)

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Kajikawa M, Yamaguchi K, Okada N.
A new mechanism to ensure integration during LINE retrotransposition: A suggestion from analyses of the 5' extra nucleotides.
Gene. in press (2012)


Nakamura M, Kajikawa M, Okada N.
Self-Interaction, Nucleic Acid Binding, and Nucleic Acid Chaperone Activities Are Unexpectedly Retained in the Unique ORF1p of Zebrafish LINE.
Mol Cell Biol. 32, 458-69 (2012)

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Bergmann JH, Jakubsche JN, Martins NM, Kagansky A, Nakano M, Kimura H, Kelly DA, Turner BM,Masumoto H, Larionov V, Earnshaw WC.
Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function.
J Cell Sci. 125, 411-21 (2012)


Kim JH, Kononenko A, Erliandri I, Kim TA, Nakano M, Iida Y, Barrett JC, Oshimura M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.
Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells.
Proc Natl Acad Sci U S A. 108, 20048-53 (2011)

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Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto K, Takata M, Kitao H, Maehara Y.
ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.
DNA Repair (Amst). 11, 247-58 (2012)


Shigechi T, Tomida J, Sato K, Kobayashi M, Eykelenboom JK, Pessina F, Zhang Y, Uchida E, Ishiai M, Lowndes NF, Yamamoto K, Kurumizaka H, Maehara Y, Takata M.
ATR-ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway.
Cancer Res. 72, 1149-56 (2012)


Rosado IV, Langevin F, Crossan GP, Takata M, Patel KJ.
Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.
Nat Struc and Mol Biol. 18, 1432-4 (2011)


Bell DW, Sikdar N, Lee KY, Price JC, Chatterjee R, Park HD, Fox J, Ishiai M, Rudd ML, Pollock LM, Fogoros SK, Mohamed H, Hanigan CL; NISC Comparative Sequencing Program, Zhang S, Cruz P, Renaud G, Hansen NF, Cherukuri PF, Borate B, McManus KJ, Stoepel J, Sipahimalani P, Godwin AK, Sgroi DC, Merino MJ, Elliot G, Elkahloun A, Vinson C, Takata M, Mullikin JC, Wolfsberg TG, Hieter P, Lim DS, Myung K.
Predisposition to cancer caused by genetic and functional defects of mammalian Atad5.
PLoS Genet. e1002245 (2011)


Matsushita N, Endo Y, Sato K, Kurumizaka H, Yamashita T, Takata M, Yanagi S.
Direct inhibition of TNF-α promoter activity by Fanconi anemia protein FANCD2.
PLoS One. 6, e23324 (2011)


Kitao H, Hirano S, Takata M.
Evaluation of homologous recombinational repair in chicken B lymphoma cell line, DT40.
Methods Mol Biol. 745, 293-309 (2011)


Takata M.
Guest editorial: fanconi anemia and the DNA damage response.
Int J Hematol. 93, 415-6 (2011)


Yamamoto KY, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K.
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
Proc Natl Acad Sci U S A. 108, 6492-6 (2011)


Guervilly JH, Renaud E, Takata M, Rosselli F.
USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation.
Hum Mol Genet. 20, 171-81 (2011)


Hosono Y, Abe T, Ishiai M, Takata M, Enomoto T, Seki M.
The role of SNM1 family nucleases in etoposide-induced apoptosis.
Biochem Biophys Res Commun. 410, 568-73 (2011)


Kitao H, Nanda I, Sugino RP, Kinomura A, Yamazoe M, Arakawa H, Schmid M, Innan H, Hiom K,Takata M.
FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells.
Genes Cells. 16, 714-27 (2011)


Kitao H, Takata M.
Fanconi anemia: a disorder defective in the DNA damage response.
Int J Hematol. 93, 417-24 (2011)

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