Hideaki TAGAMI
- Room
- Building 1, 7-709
- dan@nsc.nagoya-cu.ac.jp
- TEL
- +81-52-872-5818
- URL
- https://www.nsc.nagoya-cu.ac.jp/labs/dan/
- Division
- Biological Science, Associate Professor
- Academic Degree
- Doctor of Science
| Research Field | Molecular Biology, Chromatin Regulation |
|---|---|
| Keywords | Chromatin regulation, Histone complexes, |
| Current Research Topics | The research of this group focuses on chromatin regulation using a strategy of protein complex analysis. We address the molecular mechanisms through functional analyses of the interaction partners of histones in yeast. The major projects are the following: (1) Molecular mechanisms of chromatin assembly We are studying the histone deposition machinery to understand the molecular events leading to chromatin assembly. (2) Chromatin regulation on gene expression We are interested in the connections between histone dynamics and transcription. (3) Histone metabolism and cell cycle We investigate the regulations of histone’s life: from the synthesis to degradation, and the molecular link between the regulation and cell cycle progression. |
| Selected Publications | Purification of Histone Variant-Interacting Chaperone Complexes. Methods in Molecular Biology, 1832, 51-60 (2018) HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres., Cell, 137, 487-497 (2009). From the view of histone complexes: A sketch of molecular players on the chromatin assembly events. In “DNA Structure, Chromatin and Gene Expression” Transworld Research Network, 57, 145-158 (2006). Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis, Cell, 116, 51-61 (2004). |